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The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRLMP-lprlpr mice
MRL/MP-lpr/lpr (MRL/lpr) mice develop a spontaneous autoimmune disease. Serum from these mice contained significantly higher concentrations of nitrite/nitrate than serum from age-matched controlExpand
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A Proinflammatory Role of IL-18 in the Development of Spontaneous Autoimmune Disease1
Serum from patients with systemic lupus erythematosus (SLE) contained significantly higher concentrations of IL-18 than normal individuals. MRL/lpr mice, which develop spontaneous lupus-likeExpand
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The distribution of epithelial membrane antigen in the kidney and its tumours
The distribution of epithelial membrane antigen (EMA) in the kidney and its tumours has been studied using a polyclonal anti‐EMA antiserum and the immunoperoxidase‐antiperoxidase technique (PAP).Expand
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Tuft‐to‐capsule adhesions and their precursors: differences between the vascular and tubular poles of the human glomerulus
Human glomerular capillary tufts were removed by microdissection and scanning electron microscopy was used to examine the surface of the capillary tuft and the interior of its Bowman's capsule inExpand
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Cardiac function and coronary arteriography in asymptomatic Type 1 (insulin-dependent) diabetic patients: Evidence for a specific diabetic heart disease
SummaryCardiac function was examined in 63 asymptomatic Type 1 (insulin-dependent) diabetic patients, aged 30–50 years, using radionuclide ventriculography and exercise electrocardiography toExpand
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Intrauterine growth restriction is associated with persistent juxtamedullary expression of renin in the fetal kidney.
BACKGROUND Intrauterine growth restriction (IUGR) has been linked to impaired renal function and hypertension, suggesting that an adverse prenatal environment could alter kidney development and reninExpand
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The anatomy of the renin-secreting cell in adult polycystic kidney disease.
We used a human renin antiserum and an immunoperoxidase method to investigate the distribution of renin-containing cells in 19 adult polycystic kidneys: 9 autopsy and 10 nephrectomy cases. TheseExpand
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The parietal podocyte: a study of the vascular pole of the human glomerulus.
The vascular pole of the glomerulus is an important area of the nephron. The function of the juxtaglomerular apparatus (JGA) and the anatomical relationships of its tubular, glomerular and vascularExpand
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Renin Gene Expression in Fetal Kidneys of Pregnancies Complicated by Twin-Twin Transfusion Syndrome
AbstractTwin-twin transfusion syndrome (TTTS) complicates one in five monochorionic pregnancies and is generally associated with high mortality and morbidity. One twin (the recipient) growsExpand
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Hypertension associated with increased renin concentrations in nephroblastoma.
An infant with severe hypertension who had a nephroblastoma which was secreting active renin is described. Nephroblastoma must be included in the differential diagnosis of hypertension associatedExpand
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