Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
Rapid Conversion of Fibroblasts into Functional Forebrain GABAergic Interneurons by Direct Genetic Reprogramming.
- G. Colasante, G. Lignani, +18 authors V. Broccoli
- Biology, Medicine
- Cell stem cell
- 3 December 2015
Transplantation of GABAergic interneurons (INs) can provide long-term functional benefits in animal models of epilepsy and other neurological disorders. Whereas GABAergic INs can be differentiated… Expand
Direct Conversion of Fibroblasts into Functional Astrocytes by Defined Transcription Factors
- M. Caiazzo, S. Giannelli, +10 authors V. Broccoli
- Biology, Medicine
- Stem cell reports
- 31 December 2014
Summary Direct cell reprogramming enables direct conversion of fibroblasts into functional neurons and oligodendrocytes using a minimal set of cell-lineage-specific transcription factors. This… Expand
Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels
- L. Medrihan, F. Cesca, A. Raimondi, G. Lignani, P. Baldelli, F. Benfenati
- Biology, Medicine
- Nature communications
- 26 February 2013
In the central nervous system, most synapses show a fast mode of neurotransmitter release known as synchronous release followed by a phase of asynchronous release, which extends over tens of… Expand
Phosphorylation of Synapsin I by Cyclin-Dependent Kinase-5 Sets the Ratio between the Resting and Recycling Pools of Synaptic Vesicles at Hippocampal Synapses
- Anne M J Verstegen, E. Tagliatti, +9 authors F. Benfenati
- Biology, Medicine
- The Journal of Neuroscience
- 21 May 2014
Cyclin-dependent kinase-5 (Cdk5) was reported to downscale neurotransmission by sequestering synaptic vesicles (SVs) in the release-reluctant resting pool, but the molecular targets mediating this… Expand
TAAR1 Modulates Cortical Glutamate NMDA Receptor Function
- S. Espinoza, G. Lignani, +15 authors R. Gainetdinov
- Psychology, Medicine
- Neuropsychopharmacology
- 1 August 2015
Trace Amine-Associated Receptor 1 (TAAR1) is a G protein-coupled receptor expressed in the mammalian brain and known to influence subcortical monoaminergic transmission. Monoamines, such as dopamine,… Expand
Epileptogenic Q555X SYN1 mutant triggers imbalances in release dynamics and short-term plasticity
- G. Lignani, A. Raimondi, +9 authors F. Benfenati
- Biology, Medicine
- Human molecular genetics
- 12 February 2013
Synapsin I (SynI) is a synaptic vesicle (SV) phosphoprotein playing multiple roles in synaptic transmission and plasticity by differentially affecting crucial steps of SV trafficking in excitatory… Expand
Long-term optical stimulation of channelrhodopsin-expressing neurons to study network plasticity
- G. Lignani, E. Ferrea, +7 authors F. Benfenati
- Biology, Medicine
- Front. Mol. Neurosci.
- 20 August 2013
Neuronal plasticity produces changes in excitability, synaptic transmission, and network architecture in response to external stimuli. Network adaptation to environmental conditions takes place in… Expand
REST/NRSF‐mediated intrinsic homeostasis protects neuronal networks from hyperexcitability
- D. Pozzi, G. Lignani, +10 authors P. Baldelli
- Biology, Medicine
- The EMBO journal
- 13 November 2013
Intrinsic homeostasis enables neuronal circuits to maintain activity levels within an appropriate range by modulating neuronal voltage‐gated conductances, but the signalling pathways involved in this… Expand
Synapsins: from synapse to network hyperexcitability and epilepsy.
- A. Fassio, Andrea Raimondi, G. Lignani, F. Benfenati, P. Baldelli
- Biology, Medicine
- Seminars in cell & developmental biology
- 1 June 2011
The synapsin family in mammals consists of at least 10 isoforms encoded by three distinct genes and composed by a mosaic of conserved and variable domains. Synapsins, although not essential for the… Expand
Strategies to maximize the performance of a STED microscope.
- Silvia Galiani, B. Harke, +4 authors P. Bianchini
- Physics, Medicine
- Optics express
- 26 March 2012
In stimulated emission depletion (STED) microscopy, the spatial resolution scales as the inverse square root of the STED beam's intensity. However, to fully exploit the maximum effective resolution… Expand