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- Publications
- Influence
Rapid Conversion of Fibroblasts into Functional Forebrain GABAergic Interneurons by Direct Genetic Reprogramming.
- G. Colasante, G. Lignani, +18 authors V. Broccoli
- Biology, Medicine
- Cell stem cell
- 3 December 2015
Transplantation of GABAergic interneurons (INs) can provide long-term functional benefits in animal models of epilepsy and other neurological disorders. Whereas GABAergic INs can be differentiated… Expand
Direct Conversion of Fibroblasts into Functional Astrocytes by Defined Transcription Factors
- M. Caiazzo, S. Giannelli, +10 authors V. Broccoli
- Biology, Medicine
- Stem cell reports
- 31 December 2014
Summary Direct cell reprogramming enables direct conversion of fibroblasts into functional neurons and oligodendrocytes using a minimal set of cell-lineage-specific transcription factors. This… Expand
Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels
- L. Medrihan, F. Cesca, A. Raimondi, G. Lignani, P. Baldelli, F. Benfenati
- Biology, Medicine
- Nature communications
- 26 February 2013
In the central nervous system, most synapses show a fast mode of neurotransmitter release known as synchronous release followed by a phase of asynchronous release, which extends over tens of… Expand
Phosphorylation of Synapsin I by Cyclin-Dependent Kinase-5 Sets the Ratio between the Resting and Recycling Pools of Synaptic Vesicles at Hippocampal Synapses
- Anne M J Verstegen, E. Tagliatti, +9 authors F. Benfenati
- Biology, Medicine
- The Journal of Neuroscience
- 21 May 2014
Cyclin-dependent kinase-5 (Cdk5) was reported to downscale neurotransmission by sequestering synaptic vesicles (SVs) in the release-reluctant resting pool, but the molecular targets mediating this… Expand
TAAR1 Modulates Cortical Glutamate NMDA Receptor Function
- S. Espinoza, G. Lignani, +15 authors R. Gainetdinov
- Psychology, Medicine
- Neuropsychopharmacology
- 1 August 2015
Trace Amine-Associated Receptor 1 (TAAR1) is a G protein-coupled receptor expressed in the mammalian brain and known to influence subcortical monoaminergic transmission. Monoamines, such as dopamine,… Expand
Epileptogenic Q555X SYN1 mutant triggers imbalances in release dynamics and short-term plasticity
- G. Lignani, A. Raimondi, +9 authors F. Benfenati
- Biology, Medicine
- Human molecular genetics
- 12 February 2013
Synapsin I (SynI) is a synaptic vesicle (SV) phosphoprotein playing multiple roles in synaptic transmission and plasticity by differentially affecting crucial steps of SV trafficking in excitatory… Expand
Long-term optical stimulation of channelrhodopsin-expressing neurons to study network plasticity
- G. Lignani, E. Ferrea, +7 authors F. Benfenati
- Biology, Medicine
- Front. Mol. Neurosci.
- 20 August 2013
Neuronal plasticity produces changes in excitability, synaptic transmission, and network architecture in response to external stimuli. Network adaptation to environmental conditions takes place in… Expand
REST/NRSF‐mediated intrinsic homeostasis protects neuronal networks from hyperexcitability
- D. Pozzi, G. Lignani, +10 authors P. Baldelli
- Biology, Medicine
- The EMBO journal
- 13 November 2013
Intrinsic homeostasis enables neuronal circuits to maintain activity levels within an appropriate range by modulating neuronal voltage‐gated conductances, but the signalling pathways involved in this… Expand
Synapsins: from synapse to network hyperexcitability and epilepsy.
- A. Fassio, Andrea Raimondi, G. Lignani, F. Benfenati, P. Baldelli
- Biology, Medicine
- Seminars in cell & developmental biology
- 1 June 2011
The synapsin family in mammals consists of at least 10 isoforms encoded by three distinct genes and composed by a mosaic of conserved and variable domains. Synapsins, although not essential for the… Expand
dCas9-Based Scn1a Gene Activation Restores Inhibitory Interneuron Excitability and Attenuates Seizures in Dravet Syndrome Mice.
- G. Colasante, G. Lignani, +16 authors V. Broccoli
- Biology, Medicine
- Molecular therapy : the journal of the American…
- 8 January 2020
Dravet syndrome (DS) is a severe epileptic encephalopathy caused mainly by heterozygous loss-of-function mutations of the SCN1A gene, indicating haploinsufficiency as the pathogenic mechanism. Here… Expand