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Synthesis and SAR studies of very potent imidazopyridine antiprotozoal agents.
Variations in the turn‐forming characteristics of N‐Acyl proline units
TLDR
Variable temperature measurements indicate that for each proline derivative there is very little enthalpic difference between the intramolecularly hydrogen‐bonded and nonhydrogen bonded states of the trans rotamer, and the internally hydrogen‐ bonded state is significantly less populated for the N‐pivaloyl compound.
Novel cyclic compounds as potent phosphodiesterase 4 inhibitors.
TLDR
The synthesis and biological activity of a novel series of 2, 2-disubstituted indan-1,3-dione-based PDE4 inhibitors, which led to the identification of inhibitors with nanomolar potency and oral activity in a murine endotoxemia model for TNF-alpha inhibition.
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