G. Liang

Publications37
h-index18
Citations1,014
Highly Influential Citations4
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Conformation-directing effects of a single intramolecular amide-amide hydrogen bond: variable-temperature NMR and IR studies on a homologous diamide series
Synthesis and SAR studies of very potent imidazopyridine antiprotozoal agents.
Synthesis and SAR of 2,3-diarylpyrrole inhibitors of parasite cGMP-dependent protein kinase as novel anticoccidial agents.
An improved oxadiazole synthesis using peptide coupling reagents
An Achiral Dipeptide Mimetic That Promotes .beta.-Hairpin Formation
Variations in the turn‐forming characteristics of N‐Acyl proline units
TLDR
Variable temperature measurements indicate that for each proline derivative there is very little enthalpic difference between the intramolecularly hydrogen‐bonded and nonhydrogen bonded states of the trans rotamer, and the internally hydrogen‐ bonded state is significantly less populated for the N‐pivaloyl compound.
Thermodynamic analysis of .beta.-turn formation in Pro-Ala, Pro-Gly, and Pro-Val model peptides in methylene chloride
Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design.
Novel cyclic compounds as potent phosphodiesterase 4 inhibitors.
TLDR
The synthesis and biological activity of a novel series of 2, 2-disubstituted indan-1,3-dione-based PDE4 inhibitors, which led to the identification of inhibitors with nanomolar potency and oral activity in a murine endotoxemia model for TNF-alpha inhibition.
Optimization of 1,4-diazepan-2-one containing dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes.
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