• Publications
  • Influence
Ku acts in a unique way at the mammalian telomere to prevent end joining.
Telomeres are specialized DNA/protein structures that act as protective caps to prevent end fusion events and to distinguish the chromosome ends from double-strand breaks. We report that TRF1 and KuExpand
Correlation between synthesis of heat shock proteins and development of thermotolerance in Chinese hamster fibroblasts.
  • G. Li, Z. Werb
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 May 1982
Synthesis of a family of proteins called "heat shock" proteins is induced or enhanced in cells in response to various environmental stresses, suggesting that these proteins may perform functionsExpand
DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes.
Recent findings intriguingly place DNA double-strand break repair proteins at chromosome ends in yeast, where they help maintain normal telomere length and structure. In the present study, anExpand
Major heat shock protein hsp70 protects tumor cells from tumor necrosis factor cytotoxicity.
Heat treatment and various other stresses render tumor cells resistant to cytotoxicity mediated by tumor necrosis factors (TNFs). Here, we elucidate the molecular basis of this phenomenon byExpand
Correlation between synthesis of heat shock proteins and development of thermotolerance in Chinese hamster fibroblasts.
Synthesis of a family of proteins called "heat shock" proteins is induced or enhanced in cells in response to various environmental stresses, suggesting that these proteins may perform functionsExpand
Interaction between heat shock factor and hsp70 is insufficient to suppress induction of DNA-binding activity in vivo.
The intracellular level of free heat shock proteins, in particular the 70-kDa stress protein family, has been suggested to be the basis of an autoregulatory mechanism by which the cell measures theExpand
Ku70: a candidate tumor suppressor gene for murine T cell lymphoma.
We present evidence that inactivation of the Ku70 gene leads to a propensity for malignant transformation both in vitro and in vivo. In vitro, Ku70-/- mouse fibroblasts displayed an increased rate ofExpand
Heat shock proteins, thermotolerance, and their relevance to clinical hyperthermia.
Mammalian cells, when exposed to a non-lethal heat shock, have the ability to acquire a transient resistance to subsequent exposures at elevated temperatures, a phenomenon termed thermotolerance. TheExpand
DNA-PKcs is critical for telomere capping
The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is critical for DNA repair via the nonhomologous end joining pathway. Previously, it was reported that bone marrow cells andExpand
ATM Is Required for IκB Kinase (IKK) Activation in Response to DNA Double Strand Breaks*
Following challenge with proinflammatory stimuli or generation of DNA double strand breaks (DSBs), transcription factor NF-κB translocates from the cytoplasm to the nucleus to activate expression ofExpand
...
1
2
3
4
5
...