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Direct transesterification of all classes of lipids in a one-step reaction.
TLDR
This one-step direct transesterification procedure carried out in methanol-benzene 4:1 with acetyl chloride is superior to currently used methods not onlyBecause of its simplicity and speed, but also because of its added precision. Expand
Improved recovery of fatty acid through direct transesterification without prior extraction or purification.
  • G. Lepage, C. Roy
  • Chemistry, Medicine
  • Journal of lipid research
  • 1 December 1984
TLDR
The direct transesterification method appears to be particularly advantageous for the recovery of the highly volatile medium chain triglycerides and there is no need to add an antioxidant to protect unsaturated lipids. Expand
The potential of the hydrocarbon breath test as a measure of lipid peroxidation.
TLDR
The results of the hydrocarbon breath test are not influenced by prior food consumption, but both vitamin E and beta-carotene supplementation decrease hydrocarbon excretion, and the long-term use of a diet high in polyunsaturated fatty acids, such as in parenteral nutrition regimens, may result in increased hydrocarbon exhalation. Expand
Specific methylation of plasma nonesterified fatty acids in a one-step reaction.
  • G. Lepage, C. Roy
  • Chemistry, Medicine
  • Journal of lipid research
  • 1 February 1988
TLDR
The specificity of the methylation reaction for NEFA without hydrolysis of other classes of plasma lipids was substantiated with appropriate standards and this one-step specific methylation procedure is superior to currently used methods. Expand
Direct transesterification of plasma fatty acids for the diagnosis of essential fatty acid deficiency in cystic fibrosis.
TLDR
This study aimed at redefining criteria for essential fatty acid (EFA) deficiency with the use of the direct transesterification procedure and determining whether a simple assay of total fatty acids (FA) is as predictive of EFA deficiency as the FA pattern from plasma, red cell, and platelet phospholipids. Expand
Increased levels of plasma malondialdehyde in Friedreich ataxia.
TLDR
Several lines of evidence support the hypothesis that similar mechanisms are involved in the human disease, and data from yeast suggest that frataxin deficiency results in mitochondrial dysfunction and free radical damage. Expand
Circulating lipids and lipoproteins in glycogen storage disease type I with nocturnal intragastric feeding.
TLDR
The data suggest that glycogen storage disease type I patients on nocturnal intragastric feeding remain at risk for atherosclerosis and its complications. Expand
Contiguous deletion of the X-linked adrenoleukodystrophy gene (ABCD1) and DXS1357E: a novel neonatal phenotype similar to peroxisomal biogenesis disorders.
TLDR
Three newborn boys who had clinical symptoms and initial biochemical results consistent with PBD or SED are identified, and it is shown that they lacked ALDP, and deletions that extended into the promoter region of ABCD1 and the neighboring gene, DXS1357E are identified. Expand
Hepatobiliary disease in cystic fibrosis: a survey of current issues and concepts.
TLDR
The possibility that correction of the abnormalities of bile acid metabolism could slow the progress or prevent CF cirrhosis is discussed in light of recent experimental data. Expand
Storage of medium-chain triglycerides in adipose tissue of orally fed infants.
TLDR
This study documents that MCFAs are not used solely as a source of energy: they can be reesterified or serve for chain elongation, before being deposited in fat stores. Expand
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