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Anxiolytic Effects in Mice of a Dual Blocker of Fatty Acid Amide Hydrolase and Transient Receptor Potential Vanilloid Type-1 Channels
TLDR
Simultaneous ‘indirect’ activation of CB1 receptors following FAAH inhibition, and antagonism at TRPV1 receptors might represent a new therapeutic strategy against anxiety.
Current drug treatments targeting dopamine D3 receptor.
New pharmacological strategies for treatment of Alzheimer's disease: focus on disease modifying drugs.
TLDR
In a chronic, slow progressing pathological process, such as AD, an early start of treatment enhances the chance of success, it is crucial to have biomarkers for early detection of AD-related brain dysfunction, usable before clinical onset.
Molecular features of interaction between VEGFA and anti-angiogenic drugs used in retinal diseases: a computational approach
TLDR
The anti-angiogenic agents have been found to be considerably different both in terms of molecular interactions and stabilizing energy.
Dopamine D3 Receptor Is Necessary for Ethanol Consumption: An Approach with Buspirone
TLDR
DA signaling via D3R is essential for ethanol-related reward and consumption and may represent a novel therapeutic target for weaning and evaluated buspirone, an approved drug for anxiety disorders endowed with D3 R antagonist activity, that resulted effective in inhibiting ethanol intake.
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