G. Leggio

Publications109
h-index30
Citations2,654
Highly Influential Citations87
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Anxiolytic Effects in Mice of a Dual Blocker of Fatty Acid Amide Hydrolase and Transient Receptor Potential Vanilloid Type-1 Channels
TLDR
Simultaneous ‘indirect’ activation of CB1 receptors following FAAH inhibition, and antagonism at TRPV1 receptors might represent a new therapeutic strategy against anxiety.
View on Nature
Current drug treatments targeting dopamine D3 receptor.
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New pharmacological strategies for treatment of Alzheimer's disease: focus on disease modifying drugs.
TLDR
In a chronic, slow progressing pathological process, such as AD, an early start of treatment enhances the chance of success, it is crucial to have biomarkers for early detection of AD-related brain dysfunction, usable before clinical onset.
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Behavioral effects of the beta3 adrenoceptor agonist SR58611A: is it the putative prototype of a new class of antidepressant/anxiolytic drugs?
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P2X7 receptor antagonism: Implications in diabetic retinopathy
View on Wolters Kluwer
Molecular features of interaction between VEGFA and anti-angiogenic drugs used in retinal diseases: a computational approach
TLDR
The anti-angiogenic agents have been found to be considerably different both in terms of molecular interactions and stabilizing energy.
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Dopamine D3 Receptor Is Necessary for Ethanol Consumption: An Approach with Buspirone
TLDR
DA signaling via D3R is essential for ethanol-related reward and consumption and may represent a novel therapeutic target for weaning and evaluated buspirone, an approved drug for anxiety disorders endowed with D3 R antagonist activity, that resulted effective in inhibiting ethanol intake.
View on Nature
The PKCbeta/HuR/VEGF pathway in diabetic retinopathy.
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The dual blocker of FAAH/TRPV1 N-arachidonoylserotonin reverses the behavioral despair induced by stress in rats and modulates the HPA-axis.
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Enhanced cognitive performance of dopamine D3 receptor "knock-out" mice in the step-through passive-avoidance test: assessing the role of the endocannabinoid/endovanilloid systems.
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