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Barriers and facilitators for clinical trial participation among diverse Asian patients with breast cancer: a qualitative study
BackgroundRecruitment rates for cancer trials are low for racial/ethnic minorities. Little is known about factors influencing trial recruitment in Asian patients. Our aim is to examine the barriers… Expand
Brain-derived neurotrophic factor genetic polymorphism (rs6265) is protective against chemotherapy-associated cognitive impairment in patients with early-stage breast cancer
Background Brain-derived neurotrophic factor (BDNF), a neurotrophin that regulates neuronal function and development, is implicated in several neurodegenerative conditions. Preliminary data suggest… Expand
Examining the effects of metformin on survival outcome in stage II/III colorectal cancer patients with diabetes mellitus.
3589 Background: Insulin resistance and deregulation of the insulin-like growth factor (IGF) axis is implicated in colonic carcinogenesis. Metformin inhibits hepatic gluconeogenesis and increases… Expand
Prognosis of pregnancy-associated breast cancer
Conventionally, breast cancer diagnosed during pregnancy and within the years following have been referred to collectively as pregnancy-associated breast cancer. However, increasing evidence suggests… Expand
Association of mitochondrial DNA content in peripheral blood with cancer-related fatigue and chemotherapy-related cognitive impairment in early-stage breast cancer patients: a prospective cohort study
- Jung-Woo Chae, Peh Siang Chua, +17 authors A. Chan
- Breast Cancer Research and Treatment
- 8 January 2018
PurposeCancer-related fatigue (CRF) and chemotherapy-related cognitive impairment (CRCI) are reported to be associated with mitochondrial dysfunction. Hence, mitochondrial DNA (mtDNA) content, a… Expand
Distinct and heterogeneous trajectories of self‐perceived cognitive impairment among Asian breast cancer survivors
Currently, there are no studies that have established the self‐perceived cognitive trajectories experienced by breast cancer patients (BCPs) post‐chemotherapy. Therefore, we characterized the… Expand
Evaluation of brain-derived neurotrophic factor (BDNF) genetic polymorphism (rs6265) on chemotherapy-associated cognitive impairment in early-stage breast cancer (ESBC) patients.
9616 Background: BDNF is a neurotrophin that regulates neuronal function and development, which is implicated in several neurodegenerative conditions. There is preliminary data to suggest that the ...
Replication and Meta-analysis of the Association between BDNF Val66Met Polymorphism and Cognitive Impairment in Patients Receiving Chemotherapy
Cancer-related cognitive impairment (CRCI) adversely affects cancer patients. We had previously demonstrated that the BDNF Val66Met genetic polymorphism is associated with lower odds of subjective… Expand
Detection and prognostic relevance of circulating tumour cells (CTCs) in Asian breast cancers using a label-free microfluidic platform
Objectives We aimed to study the prevalence of CTCs in breast cancer (BC) patients undergoing neoadjuvant or palliative therapy with a label-free microfluidic platform (ClearCell FX), and its… Expand
A genome-wide association study (GWAS) meta-analysis of chemotherapy-associated cognitive impairment (CACI) in Asian early-stage breast cancer patients (ESBC).
10096Background: Genetic variations among genes regulating neuronal function, neurotransmission and plasticity may contribute to varying risk of CACI. In order to fully elucidate the complex geneti...