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Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL) 2014
- S. Sarin, C. Kedarisetty, +37 authors the Apasl Aclf Working Party
- Hepatology International
- 1 March 2009
The original proposed definition of ACLF was found to withstand the test of time and identify a homogenous group of patients presenting with liver failure, which led to the development of the final AARC consensus. Expand
Chronic Infection With Camelid Hepatitis E Virus in a Liver Transplant Recipient Who Regularly Consumes Camel Meat and Milk.
This finding links consumption of camel-derived food products to post-transplantation hepatitis E, which, if detected at early stages, can be cured with antiviral therapy and reduced administration of immunosuppressive agents. Expand
Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update
The original definition of ACLF was found to withstand the test of time and be able to identify a homogenous group of patients presenting with liver failure and new management options including the algorithms for the management of coagulation disorders, renal replacement therapy, sepsis, variceal bleed, antivirals and criteria for liver transplantation for ACLF patients were proposed. Expand
Increased Survival for Patients With Cirrhosis and Organ Failure in Liver Intensive Care and Validation of the Chronic Liver Failure-Sequential Organ Failure Scoring System.
- M. Mcphail, D. Shawcross, +9 authors J. Wendon
- Clinical gastroenterology and hepatology : the…
- 1 July 2015
The proportion of patients with cirrhosis who survived after admission to intensive care increased from 2000 to 2010, and SOFA and CLIF-SOFA scores during the first week of critical care appear to have similar abilities to predict patient survival. Expand
Hepatitis B pregenomic RNA splicing--the products, the regulatory mechanisms and its biological significance.
A novel protein produced by a singly spliced viral genome which was detected in vivo, containing well-defined epitopes, was shown to induce specific T-cell responses in peripheral blood mononuclear cells from infected patients. Expand
Systemic inflammatory response syndrome in acute‐on‐chronic liver failure: Relevance of ‘golden window’: A prospective study
- A. Choudhury, M. Kumar, +36 authors S. Sarin
- Journal of gastroenterology and hepatology
- 1 December 2017
The study investigated the course and outcome of ACLF patients without SIRS/sepsis, finding that patients without the condition are at higher risk of developing sepsis than those with the condition. Expand
Patterns of mutation within an emerging endemic lineage of HEV‐3a
- Yuan O Zhu, Pauline Aw, M. Aung, Hong Lee, M. Hibberd, G. Lee
- Biology, Medicine
- Journal of viral hepatitis
- 1 January 2019
Deep sequencing of viral populations from 15 immunocompromised patients with chronic HEV to identify the viral lineage and describe viral mutational hotspots within and across patients reveals variable viral population complexity during infections. Expand
Plasma exchange in patients with acute and acute-on-chronic liver failure: A systematic review
The level of evidence for use of high volume plasma exchange in selected ALF cases is high and well-designed randomized control trials will need to be carried out to ascertain the optimal duration and amount of plasma exchange required and assess if the use of High Volume Plasma Exchange can be extrapolated to patients with ACLF. Expand
Development of a new patient-derived xenograft humanised mouse model to study human-specific tumour microenvironment and immunotherapy
The human immune system in the humanised mouse (humice) models provides a model for immune-oncology study and a useful parallel-to-human platform for anti-HCC drug testing, especially immunotherapy. Expand
Drug-Induced Acute-on-Chronic Liver Failure in Asian Patients.
- H. Devarbhavi, A. Choudhury, +47 authors S. Sarin
- The American journal of gastroenterology
- 1 June 2019
Drugs are important identifiable causes of ACLF in Asia-Pacific countries, predominantly from complementary and alternative medications, followed by antituberculosis drugs. Expand