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Psychobiological risk factors for vulnerability to psychostimulants in human adolescents and animal models
Cocaine sensitization in periadolescent and adult rats.
- G. Laviola, R. D. Wood, C. Kuhn, R. Francis, L. Spear
- Psychology, BiologyThe Journal of pharmacology and experimental…
- 1 October 1995
Periadolescent rats of both sexes showed sensitization to the locomotor activating effects (matrix crossings) of Coc, whereas a consistent sensitization profile for both stereotyped head scanning and focused sniffing activities were found in adults but not in periadolescents.
Ontogenesis of behavioral sensitization and conditioned place preference induced by psychostimulants in laboratory rodents
Risk-taking behavior in adolescent mice: psychobiological determinants and early epigenetic influence
A unique hormonal and behavioral hyporesponsivity to both forced novelty and d-amphetamine in periadolescent mice
Windows of vulnerability to psychopathology and therapeutic strategy in the adolescent rodent model
Modelling the adolescent phase in rats and mice appears to be useful for the investigation of determinants of vulnerability to addiction and to other early-onset neuropsychiatric disorders.
Evidence for Enhanced Neurobehavioral Vulnerability to Nicotine during Periadolescence in Rats
Exposure to nicotine during periadolescence, but not a similar exposure in the postadolescent period, increased the intravenous self-administration of nicotine and the expression of distinct subunits of the ligand-gated acetylcholine receptor in adult animals, indicating an increased sensitivity to the addictive properties of nicotine.
Environmental enrichment during adolescence reverses the effects of prenatal stress on play behaviour and HPA axis reactivity in rats
- S. Morley-Fletcher, M. Rea, S. Maccari, G. Laviola
- Biology, PsychologyThe European journal of neuroscience
- 1 December 2003
Results clearly indicate that rats prenatally exposed to stress can benefit during periadolescence from the modulatory effects of an enriched environment and confirm that PS may well represent a suitable animal model for the design and testing of new therapeutic strategies for behavioural disorders produced by early insults.
Neurobehavioral adaptations to methylphenidate: The issue of early adolescent exposure
Elevated novelty seeking and peculiar d-amphetamine sensitization in periadolescent mice compared with adult mice.
Adult and periadolescents in the latter group exhibited a greater sensitization of the locomotor response, but did not show the compulsive licking typical of adults, and appears to be a useful model to study psychobiological risk factors involved in vulnerability to addiction during human adolescence.