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painless, a Drosophila Gene Essential for Nociception
In response to the touch of a probe heated above 38 degrees C, Drosophila larvae produce a stereotypical rolling behavior, unlike the response to an unheated probe, and a genetic screen for mutants defective in this noxious heat response was identified, identifying the painless gene. Expand
Oscillations and Sparsening of Odor Representations in the Mushroom Body
The results provide direct support for the functional relevance of correlation codes and shed some light on the role of oscillatory synchronization in sensory networks. Expand
Role of GABAergic Inhibition in Shaping Odor-Evoked Spatiotemporal Patterns in the Drosophila Antennal Lobe
It is shown that many axonless local neurons (LNs) in the adult antennal lobe are GABAergic, suggesting a cellular basis for odor- and glomerulus-dependent patterns of inhibition and consistent with a model in which odors elicit stimulus-specific spatial patterns of GABA release. Expand
Impaired odour discrimination on desynchronization of odour-encoding neural assemblies
Honeybees are used to demonstrate that odour encoding involves, as it does in locusts, the oscillatory synchronization of assemblies of projection neurons and that this synchronization is also selectively abolished by picrotoxin, an antagonist of the GABAA (γ-aminobutyric acid) receptor. Expand
Computation of Object Approach by a Wide-Field, Motion-Sensitive Neuron
The lobula giant motion detector in the locust visual system is a wide-field, motion-sensitive neuron that responds vigorously to objects approaching the animal on a collision course and might be an ideal model to investigate the biophysical implementation of a multiplication operation by single neurons. Expand
Transformation of Olfactory Representations in the Drosophila Antennal Lobe
Comparison of odor-evoked activity from afferents and postsynaptic neurons in the same glomerulus revealed that second-order neurons display broader tuning and more complex responses than their primary afferente, implicating lateral interactions within the antennal lobe. Expand
Intensity versus Identity Coding in an Olfactory System
When the encoding and decoding of odor identity and intensity by neurons in the antennal lobe and the mushroom body, first and second relays, respectively, of the locust olfactory system were examined, concentration-specific patterns clustered by identity, resolving the apparent confound. Expand
Olfactory network dynamics and the coding of multidimensional signals
  • G. Laurent
  • Computer Science, Medicine
  • Nature Reviews Neuroscience
  • 1 November 2002
According to this hypothesis, the olfactory system actively creates a large coding space in which to place odour representations and simultaneously optimizes their distribution within it, using both oscillatory and non-periodic dynamic processes with complementary functions. Expand
Transient Dynamics versus Fixed Points in Odor Representations by Locust Antennal Lobe Projection Neurons
Steady-state measures of activity in the locust antennal lobe seem inappropriate to understand the neural code in this system because the PNs' own target neurons respond least when their PN-population input stabilized at a fixed point. Expand
Dynamical representation of odors by oscillating and evolving neural assemblies
  • G. Laurent
  • Medicine, Biology
  • Trends in Neurosciences
  • 1 November 1996
This review summarizes physiological results obtained from an insect olfactory system and presents a functional scheme for odor coding that is compatible with data from other animals, including mammals. Expand