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Novel MRI Contrast Agent for Molecular Imaging of Fibrin: Implications for Detecting Vulnerable Plaques
TLDR
Fibrin clots targeted in vitro with paramagnetic nanoparticles presented a highly detectable, homogeneous T1-weighted contrast enhancement that improved with increasing gadolinium level, suggesting that molecular imaging of fibrin-targeted param magnetic nanoparticles can provide sensitive detection and localization offibrin. Expand
Nanotechnological applications in medicine.
TLDR
Highlighting clinically available and preclinical applications, this review explores the opportunities and issues surrounding nanomedicine. Expand
Molecular imaging of angiogenesis in early-stage atherosclerosis with alpha(v)beta3-integrin-targeted nanoparticles.
TLDR
This molecular imaging approach might provide a method for defining the burden and evolution of atherosclerosis in susceptible individuals as well as responsiveness of individual patients to antiatherosclerotic therapies. Expand
Targeted nanoparticles for quantitative imaging of sparse molecular epitopes with MRI
TLDR
Quantification of the signal from cell monolayers imaged at 1.5 T demonstrated, as predicted via modeling, that only picomolar concentrations of paramagnetic perfluorocarbon nanoparticles were required for the detection and quantification of tissue factor at clinical field strengths. Expand
Magnetic resonance molecular imaging with nanoparticles
TLDR
Combining high-resolution MR molecular imaging with drug delivery will facilitate verification and quantification of treatment (ie, rational targeted therapy) and will offer new clinical approaches to many diseases. Expand
The extracellular matrix is an important source of ultrasound backscatter from myocardium.
TLDR
It is concluded that there is a direct association between the ECM and the anisotropy of backscatter within intact tissue, and that ultrasonic tissue characterization represents a potentially clinically applicable method for delineating the structure and function of theECM. Expand
Molecular Imaging of Angiogenesis in Early-Stage Atherosclerosis With &agr;v&bgr;3-Integrin–Targeted Nanoparticles
TLDR
This molecular imaging approach might provide a method for defining the burden and evolution of atherosclerosis in susceptible individuals as well as responsiveness of individual patients to antiatherosclerotic therapies. Expand
19F magnetic resonance imaging for stem/progenitor cell tracking with multiple unique perfluorocarbon nanobeacons
TLDR
PFC nanoparticles provide an unequivocal and unique signature for stem/progenitor cells, enable spatial cell localization with 19F MRI, and permit quantification and detection of multiple fluorine signatures via 19F MR spectroscopy. Expand
Quantitative “magnetic resonance immunohistochemistry” with ligand‐targeted 19F nanoparticles
Unstable atherosclerotic plaques exhibit microdeposits of fibrin that may indicate the potential for a future rupture. However, current methods for evaluating the stage of an atherosclerotic lesionExpand
Revisiting an old friend: manganese-based MRI contrast agents.
TLDR
This review has discussed both classically used small molecule based blood pool contrast agents and recently developed innovative nanoparticle-based strategies highlighting a number of successful molecular imaging examples. Expand
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