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Antagonist binding profiles of five cloned human muscarinic receptor subtypes.
TLDR
The affinity profiles of several of these antagonists at five cloned human muscarinic receptors stably expressed in Chinese hamster ovary cells are determined.
P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand‐gated ion channels
TLDR
It is concluded that trimers represent an essential element of P2X receptor structure and can aggregate to form larger complexes.
Agonists and antagonists acting at P2X receptors: selectivity profiles and functional implications
  • G. Lambrecht
  • Biology
    Naunyn-Schmiedeberg's Archives of Pharmacology
  • 19 August 2000
TLDR
This work moves the field closer to the ideal goal of classifying the recombinant and native P2X receptor subtypes on the basis of antagonist profiles by identifying a series of key P2 receptor agonists and antagonists.
NF449: a subnanomolar potency antagonist at recombinant rat P2X1 receptors
TLDR
The subnanomolar potency at rP2X1 receptors and the rank order of potency, P 2X1 >> P2X3 > P 2Y1 > P2Y2 > ecto-nucleotidases, make NF449 unique among the P2 receptor antagonists reported to date.
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