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Mikania glomerata: Phytochemical, Pharmacological, and Neurochemical Study
This extract demonstrated anxiolytic effects, which may be mediated by GABAergic system, and was able to increase GABA levels and reduce of glutamate and aspartate concentrations in mice hippocampus, which could represent an interesting therapeutical strategy in the treatment of anxiety. Expand
Evaluation of Toxic, Cytotoxic, Mutagenic, and Antimutagenic Activities of Natural and Technical Cashew Nut Shell Liquids Using the Allium cepa and Artemia salina Bioassays
The cashew nut releases a substance that is known as cashews nut shell liquid (CNSL) that has preventive, antimutagenic, and reparative effects on micronuclei and on chromosomal aberrations in the A. cepa. Expand
Diminazene aceturate—An antiparasitic drug of antiquity: Advances in pharmacology & therapeutics
A systematic review on diminazene aceturate regarding its pharmacological properties suggested promising new applications such as leishmanicidal, amebicidal,anti-pneumocystis, anti-rheumatoid arthritis, antihypertensive agent and mainly as an activator of angiotensin-converting enzyme 2. Expand
Evaluation of antioxidant capacity of the aqueous extract of Cynara scolymus L. (Asteraceae) in vitro and in Saccharomyces cerevisiae
The present study evaluated the antioxidant capacity of the aqueous extract of the leaves of Cynara scolymus on Saccharomyces cerevisiae strains, proficient and deficient in antioxidant defenses, andExpand
Effects of isopentyl ferulate on oxidative stress biomarkers and a possible GABAergic anxiolytic-like trait in Swiss mice.
IF exhibited an anxiety-like effect in mice along with a potent antioxidant capacity, and it is suppose it may have neuroprotective effects possibly via GABAergic transmission pathway. Expand
Potential involvement of oxidative stress in induction of neurodegenerative diseases: Actions, mechanisms and neurotherapeutic potential of natural antioxidants
Several studies have shown that oxidative damage to various organs of a given organism is involved in causing various diseases, and in this context, the brain is highly vulnerable to oxidative stressExpand
Pre-clinical toxicology of garcinielliptone FC, a tautomeric pair of polyprenylated benzophenone, isolated from Platonia insignis Mart seeds.
The acute toxicity study indicated that GFC treatment, at selected doses given orally and intraperitoneally, showed relatively low risk of toxicity in all test animals, suggesting that it is safe for further investigation. Expand
In Vitro and Ex Vivo Chemopreventive Action of Mauritia flexuosa Products
The promising chemopreventive potentialities of M. flexuosa fruits and their by-products and peels with higher quantities of bioactive compounds and phenolic substances before and after in vitro bioaccessibility investigation are demonstrated. Expand
In vitro effects of arylhydrocoumarin on free radicals and oxidative stress in erythrocytes and Saccharomyces cerevisiae.
The results obtained in this study suggest that 7-acetoxy-4-aryl-3,4-dihydrocoumarin can assist the development of new antioxidant products for possible use in the prevention or reduction of diseases related to oxidative stress. Expand