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Enhanced effects of novel oridonin analog CYD0682 for hepatic fibrosis.
BACKGROUND Activated hepatic stellate cells (HSCs) are responsible for excess extracellular matrix (ECM) protein deposition in liver fibrosis. Previously, our group reported that the natural compoundExpand
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Enhanced anti-fibrogenic effects of novel oridonin derivative CYD0692 in hepatic stellate cells
Oridonin, isolated from Rabdosia rubescens, has been proven to possess various anti-neoplastic and anti-inflammatory properties. Previously, we reported the anti-fibrogenic effects of oridonin forExpand
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Oridonin inhibits hepatic stellate cell proliferation and fibrogenesis.
BACKGROUND Liver fibrosis is a common response to liver injury and, in severe cases, leads to cirrhosis. The hepatic stellate cells (HSCs) become activated after liver injury and play a significantExpand
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PRETREATMENT WITH BONE MORPHOGENETIC PROTEIN-7 (BMP-7) MIMICS ISCHEMIA PRECONDITIONING FOLLOWING INTESTINAL ISCHEMIA/REPERFUSION INJURY IN THE INTESTINE AND LIVER
Intestinal ischemia/reperfusion (I/R) injury has been shown to cause intestinal mucosal injury and adversely affect function. Ischemic preconditioning (IPC) has been shown to protect againstExpand
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Heart rate variability analysis is more sensitive at identifying neonatal sepsis than conventional vital signs.
BACKGROUND Sepsis remains the largest preventable source of neonatal mortality in the world. Heart rate variability (HRV) analysis and noninvasive cardiac output have been shown to be useful adjunctsExpand
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Hypertonic saline alters hydraulic conductivity and up-regulates mucosal/submucosal aquaporin 4 in resuscitation-induced intestinal edema
Objective:To characterize membrane conductivity by applying mathematical modeling techniques and immunohistochemistry and to localize and predict areas of the bowel where aquaporins may be associatedExpand
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