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Comparative disposition of the nephrotoxicant N-(3, 5-dichlorophenyl)succinimide and the non-nephrotoxicant N-(3, 5-difluorophenyl)succinimide in Fischer 344 rats.
Disposition of the nephrotoxicant N-(3,5-dichlorophenyl)succinimide (NDPS) was compared with that of a nontoxic analog, N-(3, 5-difluorophenyl)succinimide (DFPS). Male Fischer 344 rats wereExpand
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Comparative Disposition of the NephrotoxicantN-(3,5-Dichlorophenyl)Succinimide and the Non-Nephrotoxicant N-(3,5-Difluorophenyl)Succinimide in Fischer 344 Rats
Disposition of the nephrotoxicant N -(3,5-dichlorophenyl)succinimide (NDPS) was compared with that of a nontoxic analog, N -(3,5-difluorophenyl)succinimide (DFPS). Male Fischer 344 rats wereExpand
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The effect of aromatic fluorine substitution on the nephrotoxicity and metabolism of N-(3,5-dichlorophenyl)succinimide in Fischer 344 rats.
N-(3,5-Difluorophenyl)succinimide (DFPS) is a non-toxic analogue of the nephrotoxic fungicide N-(3,5-dichlorophenyl)succinimide (NDPS). Although NDPS must be metabolized to produce renal damage, theExpand
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Cytochrome P450-mediated metabolism and nephrotoxicity of N-(3,5-dichlorophenyl)succinimide in Fischer 344 rats.
The agricultural fungicide N-(3,5-dichlorophenyl)succinimide (NDPS) is nephrotoxic in rats. Previous studies have suggested that oxidative hepatic biotransformation is required for the induction ofExpand
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Nephrotoxic potential of N-(3,5-dichlorophenyl)glutarimide and N-(3,5-dichlorophenyl)glutaramic acid in Fischer 344 rats.
The agricultural fungicide N-(3,5-dichlorophenyl)succinimide (NDPS) produces kidney damage in rats. Although many NDPS analogues have been screened as possible nephrotoxicants, the one-carbonExpand
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