• Publications
  • Influence
Transition from moderate to excessive drug intake: change in hedonic set point.
Differential access to cocaine self-administration produced two patterns of drug intake in rats. With 1 hour of access per session, drug intake remained low and stable. In contrast, with 6 hours ofExpand
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Neurobiology of addiction: a neurocircuitry analysis.
Drug addiction represents a dramatic dysregulation of motivational circuits that is caused by a combination of exaggerated incentive salience and habit formation, reward deficits and stress surfeits,Expand
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A Role for Brain Stress Systems in Addiction
  • G. Koob
  • Psychology, Medicine
  • Neuron
  • 10 July 2008
Drug addiction is a chronically relapsing disorder characterized by compulsion to seek and take drugs and has been linked to dysregulation of brain regions that mediate reward and stress. ActivationExpand
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Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: genetic and motivational determinants.
Dopaminergic neurotransmission in the nucleus accumbens may be an important factor in ethanol reinforcement and genetically determined ethanol preference. This hypothesis was tested by measuringExpand
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Drugs of abuse: anatomy, pharmacology and function of reward pathways.
  • G. Koob
  • Psychology, Medicine
  • Trends in pharmacological sciences
  • 1992
Drugs of abuse are very powerful reinforcers, and even in conditions of limited access (where the organism is not dependent) these drugs will motivate high rates of operant responding. This presumedExpand
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Alcoholism: allostasis and beyond.
  • G. Koob
  • Psychology, Medicine
  • Alcoholism, clinical and experimental research
  • 1 February 2003
Alcoholism is a chronic relapsing disorder characterized by compulsive drinking, loss of control over intake, and impaired social and occupational function. Animal models have been developed forExpand
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Effects of moderate alcohol consumption on the central nervous system.
The concept of moderate consumption of ethanol (beverage alcohol) has evolved over time from considering this level of intake to be nonintoxicating and noninjurious, to encompassing levels defined asExpand
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Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior.
Hypocretin-1 and -2 (Hcrt-1 and Hcrt-2), also referred to as orexin-A and -B, are neuropeptides synthesized by a few thousand neurons in the lateral hypothalamus. Hypocretin-containing neuronsExpand
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Corticotropin Releasing Factor Receptor 1–Deficient Mice Display Decreased Anxiety, Impaired Stress Response, and Aberrant Neuroendocrine Development
Corticotropin releasing factor (CRF) is a major integrator of adaptive responses to stress. Two biochemically and pharmacologically distinct CRF receptor subtypes (CRFR1 and CRFR2) have beenExpand
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Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress
Corticotropin-releasing hormone (Crh) is a critical coordinator of the hypothalamic-pituitary-adrenal (HPA) axis. In response to stress, Crh released from the paraventricular nucleus (PVN) of theExpand
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