• Publications
  • Influence
Neurocircuitry of Addiction
TLDR
The delineation of the neurocircuitry of the evolving stages of the addiction syndrome forms a heuristic basis for the search for the molecular, genetic, and neuropharmacological neuroadaptations that are key to vulnerability for developing and maintaining addiction.
Transition from moderate to excessive drug intake: change in hedonic set point.
TLDR
Differential access to cocaine self-administration produced two patterns of drug intake in rats, characterized by an increased early drug loading and an upward shift in the cocaine dose-response function, suggesting an increase in hedonic set point.
Neurocircuitry of Addiction
Correction to: Neuropsychopharmacology Reviews (2010) 35, 217–238; doi:10.1038/npp.2009.110; published online 26 August 2009 In this article, there is an error in Figure 4; a revised Figure 4 is
A Role for Brain Stress Systems in Addiction
  • G. Koob
  • Medicine, Psychology
    Neuron
  • 10 July 2008
TLDR
The role of brain stress systems and brain antistress systems in addiction provides novel targets for treatment and prevention of addiction and insights into the organization and function of basic brain emotional circuitry.
Drugs of abuse: anatomy, pharmacology and function of reward pathways.
  • G. Koob
  • Psychology, Medicine
    Trends in pharmacological sciences
  • 1992
TLDR
The results suggest that brain reward systems have a multidetermined neuropharmacological basis that may involve some common neuroanatomical elements.
Alcoholism: allostasis and beyond.
  • G. Koob
  • Psychology, Medicine
    Alcoholism, clinical and experimental research
  • 1 February 2003
TLDR
The allostatic model not only integrates molecular, cellular, and circuitry neuroadaptations in brain motivational systems produced by chronic alcohol ingestion with genetic vulnerability but also provides a key to translate advances in animal studies to the human condition.
Neurobiology of addiction: a neurocircuitry analysis.
TLDR
Molecular genetic studies have identified transduction and transcription factors that act in neurocircuitry associated with the development and maintenance of addiction that might mediate initial vulnerability, maintenance, and relapse associated with addiction.
Neurobiologic Advances from the Brain Disease Model of Addiction.
TLDR
It is concluded that neuroscience continues to support the brain disease model of addiction, which has led to the development of more effective methods of prevention and treatment and to more informed public health policies.
Effects of moderate alcohol consumption on the central nervous system.
TLDR
The cognitive effects of acute and chronic moderate intake of ethanol is reviewed, and although a number of studies have noted a measurable diminution in neuropsychologic parameters in habitual consumers of moderate amounts of ethanol, others have not found such changes.
Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress
TLDR
Corticotropin-releasing hormone (Crh) is a critical coordinator of the hypothalamic-pituitary-adrenal (HPA) axis and Crhr2-mutant mice are hypersensitive to stress and display increased anxiety-like behaviour.
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