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- Publications
- Influence
Transition from moderate to excessive drug intake: change in hedonic set point.
Differential access to cocaine self-administration produced two patterns of drug intake in rats. With 1 hour of access per session, drug intake remained low and stable. In contrast, with 6 hours of… Expand
Neurobiology of addiction: a neurocircuitry analysis.
Drug addiction represents a dramatic dysregulation of motivational circuits that is caused by a combination of exaggerated incentive salience and habit formation, reward deficits and stress surfeits,… Expand
A Role for Brain Stress Systems in Addiction
- G. Koob
- Psychology, Medicine
- Neuron
- 10 July 2008
Drug addiction is a chronically relapsing disorder characterized by compulsion to seek and take drugs and has been linked to dysregulation of brain regions that mediate reward and stress. Activation… Expand
Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: genetic and motivational determinants.
- F. Weiss, Marge T. Lorang, F. Bloom, G. Koob
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 October 1993
Dopaminergic neurotransmission in the nucleus accumbens may be an important factor in ethanol reinforcement and genetically determined ethanol preference. This hypothesis was tested by measuring… Expand
Drugs of abuse: anatomy, pharmacology and function of reward pathways.
- G. Koob
- Psychology, Medicine
- Trends in pharmacological sciences
- 1992
Drugs of abuse are very powerful reinforcers, and even in conditions of limited access (where the organism is not dependent) these drugs will motivate high rates of operant responding. This presumed… Expand
Alcoholism: allostasis and beyond.
- G. Koob
- Psychology, Medicine
- Alcoholism, clinical and experimental research
- 1 February 2003
Alcoholism is a chronic relapsing disorder characterized by compulsive drinking, loss of control over intake, and impaired social and occupational function. Animal models have been developed for… Expand
Effects of moderate alcohol consumption on the central nervous system.
- M. Eckardt, S. E. File, +7 authors B. Tabakoff
- Psychology, Medicine
- Alcoholism, clinical and experimental research
- 1 August 1998
The concept of moderate consumption of ethanol (beverage alcohol) has evolved over time from considering this level of intake to be nonintoxicating and noninjurious, to encompassing levels defined as… Expand
Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior.
- B. Boutrel, P. Kenny, +4 authors L. de Lecea
- Medicine
- Proceedings of the National Academy of Sciences…
- 27 December 2005
Hypocretin-1 and -2 (Hcrt-1 and Hcrt-2), also referred to as orexin-A and -B, are neuropeptides synthesized by a few thousand neurons in the lateral hypothalamus. Hypocretin-containing neurons… Expand
Corticotropin Releasing Factor Receptor 1–Deficient Mice Display Decreased Anxiety, Impaired Stress Response, and Aberrant Neuroendocrine Development
- G. W. Smith, Jean‐Michel Aubry, +11 authors Kuo-Fen Lee
- Biology, Medicine
- Neuron
- 1 June 1998
Corticotropin releasing factor (CRF) is a major integrator of adaptive responses to stress. Two biochemically and pharmacologically distinct CRF receptor subtypes (CRFR1 and CRFR2) have been… Expand
Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress
- T. Bale, A. Contarino, +6 authors Kuo-Fen Lee
- Biology, Medicine
- Nature Genetics
- 1 April 2000
Corticotropin-releasing hormone (Crh) is a critical coordinator of the hypothalamic-pituitary-adrenal (HPA) axis. In response to stress, Crh released from the paraventricular nucleus (PVN) of the… Expand