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- Publications
- Influence
Neurocircuitry of Addiction
Drug addiction is a chronically relapsing disorder that has been characterized by (1) compulsion to seek and take the drug, (2) loss of control in limiting intake, and (3) emergence of a negative… Expand
Neurocircuitry of Addiction
Correction to: Neuropsychopharmacology Reviews (2010) 35, 217–238; doi:10.1038/npp.2009.110; published online 26 August 2009 In this article, there is an error in Figure 4; a revised Figure 4 is… Expand
Neurobiologic Advances from the Brain Disease Model of Addiction.
- N. Volkow, G. Koob, A. Mclellan
- Medicine, Political Science
- The New England journal of medicine
- 27 January 2016
This article reviews scientific advances in the prevention and treatment of substance-use disorder and related developments in public policy. In the past two decades, research has increasingly… Expand
Quantification of neurosteroids in rat plasma and brain following swim stress and allopregnanolone administration using negative chemical ionization gas chromatography/mass spectrometry.
- M. Vallée, J. D. Rivera, G. Koob, R. Purdy, R. Fitzgerald
- Chemistry, Medicine
- Analytical biochemistry
- 1 December 2000
A simplified method for the quantitative analysis of neurosteroids in rat plasma and brain is described. The method uses negative chemical ionization gas chromatography/mass spectrometry and involves… Expand
The Development and Maintenance of Drug Addiction
What is the defining property of addiction? We dust off a several-decades-long debate about the relative importance of two forms of reinforcement—positive reinforcement, subjectively linked to… Expand
Preclinical studies of alcohol binge drinking
- J. J. Crabbe, R. Harris, G. Koob
- Psychology, Medicine
- Annals of the New York Academy of Sciences
- 1 January 2011
Binge drinking is prevalent and has serious biomedical consequences. In children, adolescents, and young adults, it is a prominent risk factor for later development of alcohol‐use disorders. Many… Expand
Sex Differences in Animal Models: Focus on Addiction
The purpose of this review is to discuss ways to think about and study sex differences in preclinical animal models. We use the framework of addiction, in which animal models have excellent face and… Expand
REVIEW: Alcohol‐related genes: contributions from studies with genetically engineered mice
- J. Crabbe, T. Phillips, R. Harris, M. Arends, G. Koob
- Biology, Medicine
- Addiction biology
- 1 September 2006
Since 1996, nearly 100 genes have been studied for their effects related to ethanol in mice using genetic modifications including gene deletion, gene overexpression, gene knock‐in, and occasionally… Expand
A molecular link between the active component of marijuana and Alzheimer's disease pathology.
- L. Eubanks, Claude J. Rogers, +4 authors K. Janda
- Medicine
- Molecular pharmaceutics
- 9 August 2006
Alzheimer's disease is the leading cause of dementia among the elderly, and with the ever-increasing size of this population, cases of Alzheimer's disease are expected to triple over the next 50… Expand
The Role of Corticotropin‐Releasing Factor in the Anxiogenic Effects of Ethanol Withdrawal
- F. Menzaghi, S. Rassnick, +4 authors G. Koob
- Medicine
- Annals of the New York Academy of Sciences
- 1 October 1994
In summary, endogenous CRF has been demonstrated to play an important role in the endocrine but also autonomic and behavioral responses to a stressor and to mediate some of the signs and symptoms… Expand