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Kinetics of Fatty Acid Oxidation in Low Density Lipoproteins Evaluated by Registration of the Oxidizer Consumption and Reaction Product Yield
TLDR
Comparison of the oxidation rate constants for antioxidants, arachidonic and oleic monoenic fatty acids suggests that during the lag period Cu2+-initiated forms of O2 oxidize primarily oleoic acid, whose reaction rate constant is much higher than those of antioxidants.
Antioxidants decreases the intensification of low density lipoprotein in vivo peroxidation during therapy with statins
TLDR
Antioxidants may be very effective in the prevention of atherogenic oxidative modification of LDL during HMG-CoA reductase inhibitors therapy and identified the electron spin resonance signal of probucol phenoxyl radical that suggests the interaction of LDL-associated Probucol with lipid radicals in vivo.
Mechanisms of oxidative modification of low density lipoproteins under conditions of oxidative and carbonyl stress
TLDR
A unified molecular mechanism of atherogenic action of carbonyl-modified LDL in disorders of lipid and carbohydrate metabolism is discussed.
Inhibitor of beta-hydroxy-beta-methylglutaryl coenzyme A reductase decreases energy supply to the myocardium in rats.
TLDR
Daily peroral administration of beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitor simvastatin for 30 days had no effect on the contents of macroergic phosphates (ATP and creatine phosphate) in the liver, but decreased these parameters in the myocardium.
Concentration-dependent inversion of antioxidant and prooxidant effects of β-carotene in tissuesin vivo
TLDR
Low doses (below 20 mg/kg) of oral β-carotene inhibit, while high doses activate ascorbate-dependent LPO in rat liver and myocardial cells, and anin vivo concentration-dependent inversion of β- carotene from antioxidant to prooxidant in tissues is hypothesized.
[Impact of a cold wave on disease course, hemodynamics, carbohydrate metabolism, and blood rheological properties in cardiac patents].
TLDR
The cold wave is associated with the larger number of CVEs in some patients with CVD during selected therapy, and female sex, CHD, type 2 diabetes mellitus, female sex are independent predictors of CVE in patients withCVD during the winter period.
Oxidative Stress in Atherosclerosis and Diabetes
TLDR
The results suggest that stimulation of lipid peroxidation in low-density lipoproteins during hypercholesterolemia and diabetes is associated with strong autooxidation of cholesterol and glucose during oxidative and carbonyl (aldehyde) stress, respectively.
Antioxidants decreases the intensification of low density lipoprotein in vivo peroxidation during therapy with statins
TLDR
Antioxidants may be very effective in the prevention of atherogenic oxidative modification of LDL during HMG-CoA reductase inhibitors therapy and identified the electron spin resonance signal of probucol phenoxyl radical that suggests the interaction of LDL-associated Probucol with lipid radicals in vivo.
Apelin-12 and its structural analog enhance antioxidant defense in experimental myocardial ischemia and reperfusion
TLDR
C-terminal fragment of native peptide apelin-12 and its synthesized analog is involved in the upregulation of cardiac antioxidant defense systems and attenuation of lipid peroxidation in myocardial I/R injury.
Aldehyde inhibition of antioxidant enzymes in the blood of diabetic patients
The aim of the present study was to examine the effect of aldehyde modification on antioxidant enzyme activity in diabetic patients.
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