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Nitric oxide in inflammatory bowel disease: a universal messenger in an unsolved puzzle
Knowing is updated about the role of this universal mediator and the enzymes that generate it in the pathogenesis of IBD and the mechanism by which NO proceeds from being an indispensable homeostatic regulator to a harmful destructor remains unknown.
Role of Kupffer cells in the pathogenesis of liver disease.
- G. Kolios, V. Valatas, E. Kouroumalis
- Medicine, BiologyWorld journal of gastroenterology
- 14 December 2006
A model that demonstrates the role of Kupffer cells in the pathogenesis of liver disease is proposed and it is proposed that they may represent a significant source of chemoattractant molecules for cytotoxic CD8 and regulatory T cells.
A prospective, non-randomized, no placebo-controlled, phase Ib clinical trial to study the safety of the adipose derived stromal cells-stromal vascular fraction in idiopathic pulmonary fibrosis
- A. Tzouvelekis, Vassilis Paspaliaris, Demosthenes Bouros
- MedicineJournal of Translational Medicine
- 15 July 2013
A phase Ib, non-randomized, clinical trial to study the safety of three endobronchial infusions of autologous adipose derived stromal cells -stromal vascular fraction in patients with IPF met its primary objective demonstrating an acceptable safety profile of endOBronchially administered Autologous ADSCs-SVF.
Activation of Phosphatidylinositol 3-Kinase by Interleukin-13
It is demonstrated that the activation of PtdIns 3-kinase by IL-13 is a key signal that is responsible for the inhibition of iNOS transcription in activated epithelial cells.
Expression of inducible nitric oxide synthase activity in human colon epithelial cells: modulation by T lymphocyte derived cytokines
The data suggest that the epithelium is the major source of iNOS activity in ulcerative colitis and that IL-13 and IL-4 may act as intrinsic regulators of NO generation in intestinal inflammation.
Experimental colitis models: Insights into the pathogenesis of inflammatory bowel disease and translational issues.
Probiotics and prebiotics in inflammatory bowel disease: microflora 'on the scope'.
The implication of gut flora in the intestinal inflammation that justifies the role of probiotics and prebiotics in the prevention and treatment of inflammatory bowel disease is discussed and the evidence for therapeutic benefits from their use in experimental models of colitis and clinical trials is addressed.
Introduction to Stem Cells and Regenerative Medicine
This review is an introduction to the world of stem cells and discusses their definition, origin, and classification, as well as applications of these cells in regenerative medicine.
The Chemokines CXCL9, CXCL10, and CXCL11 Differentially Stimulate Gαi-Independent Signaling and Actin Responses in Human Intestinal Myofibroblasts1
- A. Kouroumalis, R. Nibbs, H. Aptel, K. Wright, G. Kolios, S. Ward
- Biology, MedicineThe Journal of Immunology
- 15 October 2005
The biochemical responses and actin reorganization stimulated by the CXCR3 ligands in intestinal myofibroblasts are insensitive to the Gαi inhibitor, pertussis toxin.
C‐X‐C and C‐C chemokine expression and secretion by the human colonic epithelial cell line, HT‐29: differential effect of T lymphocyte‐derived cytokines
- G. Kolios, K. Wright, N. Jordan, J. Leithead, D. Robertson, J. Westwick
- Biology, MedicineEuropean journal of immunology
- 1 February 1999
It is demonstrated that colonic epithelial cell chemokine production can be differentially regulated by T cell‐derived cytokines and suggest an interplay between epithelial cells and T lymphocytes potentially important in the intestinal inflammation.