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Consensus Nomenclature for in vivo Imaging of Reversibly Binding Radioligands
- R. Innis, V. Cunningham, R. Carson
- Biology, ChemistryJournal of cerebral blood flow and metabolism…
- 9 May 2007
An international group of experts in pharmacokinetic modeling recommends a consensus nomenclature to describe in vivo molecular imaging of reversibly binding radioligands.
Blood BDNF concentrations reflect brain-tissue BDNF levels across species.
Preliminary data support the view that measures of blood and plasma BDNF levels reflect brain-tissue BDNF Levels, and find a significant positive correlation between frontal cortex and hippocampalBDNF levels in mice.
Species Differences in Blood-Brain Barrier Transport of Three Positron Emission Tomography Radioligands with Emphasis on P-Glycoprotein Transport
- S. Syvänen, O. Lindhe, M. Hammarlund-Udenaes
- Biology, ChemistryDrug Metabolism and Disposition
- 1 March 2009
Differences in plasma protein binding and metabolism did not explain the species-related differences in brain uptake of three radiolabeled P-glycoprotein substrates across species using positron emission tomography, which is important for interpretation of brain drug delivery when extrapolating preclinical data to humans.
Different partial volume correction methods lead to different conclusions: An 18F-FDG-PET study of aging
Autoregulation of Cerebral Blood Flow in Patients Resuscitated From Cardiac Arrest
- C. Sundgreen, F. Larsen, T. Herzog, G. Knudsen, S. Boesgaard, J. Aldershvile
- 1 January 2001
In a majority of patients in the acute phase after cardiac arrest, cerebral autoregulation is either absent or right-shifted, which indicates that MAP should be kept at a higher level than commonly accepted to secure cerebral perfusion.
MR-based automatic delineation of volumes of interest in human brain PET images using probability maps
The relationship between cerebral blood flow and volume in humans
Cerebral Blood Flow in Patients With Chronic Heart Failure Before and After Heart Transplantation
It is concluded that CBF is substantially, but reversibly, reduced in patients with NYHA class III/IV heart failure, which suggests that redistribution of cardiac output inadequately secures brain perfusion in Patients with severe CHF.
Cortical surface-based analysis reduces bias and variance in kinetic modeling of brain PET data