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Production of a New Thiopeptide Antibiotic, TP-1161, by a Marine Nocardiopsis Species
TLDR
The in vitro antibacterial activity of this thiopeptide, designated TP-1161, against a panel of bacterial strains was determined and structure elucidation revealed this compound to be a new thiOPEptide antibiotic with a rare aminoacetone moiety.
Cell release from alginate immobilized Lactococcus lactis ssp. lactis in chitosan and alginate coated beads.
TLDR
To examine whether the observed effects of bead coating could be explained only by a decrease in cell activity, the ratios between the rate of cell release and the rates of lactate production were examined and showed qualitatively the same behavior as direct results of volumetric cell release.
Overcoming Drug Resistance with Alginate Oligosaccharides Able To Potentiate the Action of Selected Antibiotics
TLDR
The feasibility of reducing the tolerance of wound biofilms to antibiotics with the use of specific alginate preparations is demonstrated, as seen by decreased biomass and increased intercellular spaces, with the bacterial cells themselves becoming distorted and uneven due to apparently damaged cell membranes.
Violacein-Producing Collimonas sp. from the Sea Surface Microlayer of Costal Waters in Trøndelag, Norway
TLDR
A new strain belonging to the genus Collimonas was isolated from the sea surface microlayer off the coast of Trøndelag, Norway and produced an antibacterial compound active against Micrococcus luteus, known to be produced by several marine-derived bacteria.
Global Assessment of Mycobacterium avium subsp. hominissuis Genetic Requirement for Growth and Virulence
TLDR
A highly transformable, virulent MAH clinical isolate susceptible to high-density transposon mutagenesis is identified and sequenced, facilitating global gene disruption and subsequent investigation of MAH gene function.
Insights into the Evolution of Macrolactam Biosynthesis through Cloning and Comparative Analysis of the Biosynthetic Gene Cluster for a Novel Macrocyclic Lactam, ML-449
TLDR
A phylogenetic analysis of the β-ketosynthase domains from polyketide synthases involved in the biosynthesis of macrolactams pointed to a common ancestry for the two clusters, indicating an evolutionary relationship between them and provided new insights into the processes governing the evolution of small-ringmacrolactam biosynthesis.
Alginate Oligosaccharides Inhibit Fungal Cell Growth and Potentiate the Activity of Antifungals against Candida and Aspergillus spp
TLDR
The ability of OligoG to perturb fungal growth and potentiate conventional antifungal agents was evaluated using a range of pathogenic fungal strains and a potential role in the management of fungal infections and possible reduction of antif fungus toxicity is suggested.
A high-throughput drug combination screen of targeted small molecule inhibitors in cancer cell lines
TLDR
A dataset comprising 171 pairwise combinations of 19 individual drugs targeting signal transduction mechanisms across eight cancer cell lines is presented, where the effect of each drug and drug combination is reported as cell viability assessed by metabolic activity.
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