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Production of a New Thiopeptide Antibiotic, TP-1161, by a Marine Nocardiopsis Species
The in vitro antibacterial activity of this thiopeptide, designated TP-1161, against a panel of bacterial strains was determined and structure elucidation revealed this compound to be a new thiOPEptide antibiotic with a rare aminoacetone moiety.
Cell release from alginate immobilized Lactococcus lactis ssp. lactis in chitosan and alginate coated beads.
- G. Klinkenberg, K. Q. Lystad, Levine TDW, N. Dyrset
- Chemistry, MedicineJournal of dairy science
- 1 May 2001
To examine whether the observed effects of bead coating could be explained only by a decrease in cell activity, the ratios between the rate of cell release and the rates of lactate production were examined and showed qualitatively the same behavior as direct results of volumetric cell release.
Overcoming Drug Resistance with Alginate Oligosaccharides Able To Potentiate the Action of Selected Antibiotics
- S. Khan, A. Tøndervik, David W. Thomas
- Biology, MedicineAntimicrobial Agents and Chemotherapy
- 23 July 2012
The feasibility of reducing the tolerance of wound biofilms to antibiotics with the use of specific alginate preparations is demonstrated, as seen by decreased biomass and increased intercellular spaces, with the bacterial cells themselves becoming distorted and uneven due to apparently damaged cell membranes.
Selection of candidate probionts by two different screening strategies from Atlantic cod (Gadus morhua L.) larvae.
Biosynthesis of macrolactam BE-14106 involves two distinct PKS systems and amino acid processing enzymes for generation of the aminoacyl starter unit.
Violacein-Producing Collimonas sp. from the Sea Surface Microlayer of Costal Waters in Trøndelag, Norway
A new strain belonging to the genus Collimonas was isolated from the sea surface microlayer off the coast of Trøndelag, Norway and produced an antibacterial compound active against Micrococcus luteus, known to be produced by several marine-derived bacteria.
Global Assessment of Mycobacterium avium subsp. hominissuis Genetic Requirement for Growth and Virulence
A highly transformable, virulent MAH clinical isolate susceptible to high-density transposon mutagenesis is identified and sequenced, facilitating global gene disruption and subsequent investigation of MAH gene function.
Insights into the Evolution of Macrolactam Biosynthesis through Cloning and Comparative Analysis of the Biosynthetic Gene Cluster for a Novel Macrocyclic Lactam, ML-449
- Hanne Jørgensen, K. Degnes, A. Dikiy, Espen Fjærvik, G. Klinkenberg, S. Zotchev
- Chemistry, BiologyApplied and Environmental Microbiology
- 23 October 2009
A phylogenetic analysis of the β-ketosynthase domains from polyketide synthases involved in the biosynthesis of macrolactams pointed to a common ancestry for the two clusters, indicating an evolutionary relationship between them and provided new insights into the processes governing the evolution of small-ringmacrolactam biosynthesis.
Alginate Oligosaccharides Inhibit Fungal Cell Growth and Potentiate the Activity of Antifungals against Candida and Aspergillus spp
The ability of OligoG to perturb fungal growth and potentiate conventional antifungal agents was evaluated using a range of pathogenic fungal strains and a potential role in the management of fungal infections and possible reduction of antif fungus toxicity is suggested.
A high-throughput drug combination screen of targeted small molecule inhibitors in cancer cell lines
- Åsmund Flobak, Barbara Niederdorfer, Vu To Nakstad, L. Thommesen, G. Klinkenberg, A. Lægreid
- BiologyScientific Data
- 29 October 2019
A dataset comprising 171 pairwise combinations of 19 individual drugs targeting signal transduction mechanisms across eight cancer cell lines is presented, where the effect of each drug and drug combination is reported as cell viability assessed by metabolic activity.