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Radioiodinated 15-(p-iodophenyl)-3,3-dimethylpentadecanoic acid: a useful new agent to evaluate myocardial fatty acid uptake.
The greater myocardial retention and higher heart:blood ratios observed with DMIPP in comparison with both the 3-monomethyl-(BMIPP) and unbranched (IPP) analogs suggest that [123I]DMIPP is an excellent candidate for clinical evaluation of regional energy substrates (fatty acid) uptake. Expand
A new bioactive sesterterpene and antiplasmodial alkaloids from the marine sponge hyrtios cf. erecta.
Evaluation of the biological activity of the extracts and pure compounds toward Plasmodium falciparum, Trypanosoma brucei subsp. Expand
Antiproliferative effect of natural tetrasulfides in human breast cancer cells is mediated through the inhibition of the cell division cycle 25 phosphatases.
The inhibitory activity of tetrasulfides occurring naturally in garlic and onion towards the human Cdc25 phosphatases is reported on, suggesting phosphatase CDC25 as possible targets of naturally occuring polysulfides contributing to their anticancer properties. Expand
Selective Non-nucleoside Inhibitors of Human DNA Methyltransferases Active in Cancer Including in Cancer Stem Cells
Through a process of hit-to-lead optimization, compound 5 was found as a potent non-nucleoside DNMTi that is also selective toward other AdoMet-dependent protein methyltransferases and was less toxic in peripheral blood mononuclear cells than two other compounds tested. Expand
Synthesis and protective effects of coumarin derivatives against oxidative stress induced by doxorubicin.
4-Methyl-7,8-dihydroxycoumarin was found to exhibit an important antioxidant strength, a low cytotoxicity, and could decrease ROS (reactive oxygen species) production generated by DOX treatment without affecting DOX cytot toxicity in MCF7 cells. Expand
Synthesis and biological evaluation of novel coumarin-based inhibitors of Cdc25 phosphatases.
New coumarin-based scaffolds endowed with a selective inhibition against Cdc25A and CDC25C are reported, being 6a and 6d the most efficient inhibitors and worthy of further investigation as anticancer agents. Expand
Screening of new antioxidant molecules using flow cytometry.
A flow cytometry technique to evaluate the antioxidative properties of molecules on living cells, using a stable murine-murine hybridoma (Mark 3) cell line routinely cultured, found the selenated molecule 18 was found to be 10 times more active than Ebselen but 10 000 times less active than vitamin E. Expand
ZrCl4 or ZrOCl2 under neat conditions : Optimized green alternatives for the Biginelli reaction
Abstract Biginelli reactions were performed using either ZrCl 4 or ZrOCl 2 ·8H 2 O as catalysts under neat conditions. Shorter reaction time than most of the classical methods was required when ZrClExpand
Coumarin polysulfides inhibit cell growth and induce apoptosis in HCT116 colon cancer cells.
The novel coumarin compounds regulated the phosphatase activity of the cell cycle regulating cdc25 family members, indicating that these phosphatases are implicated in the induction of cell cycle arrest and possibly in apoptosis induction as well. Expand
Natural and Synthetic Coumarins with Effects on Inflammation
This review, which will present the different aspects of coumarins and derivatives, from natural origins or synthetically prepared, and their action on inflammation, will take into account everything published since 2004. Expand