• Publications
  • Influence
Biological Insights From 108 Schizophrenia-Associated Genetic Loci
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide associationExpand
  • 4,481
  • 153
De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia
A small number of rare, recurrent genomic copy number variants (CNVs) are known to substantially increase susceptibility to schizophrenia. As a consequence of the low fecundity in people withExpand
  • 622
  • 34
Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection
Schizophrenia is a debilitating psychiatric condition often associated with poor quality of life and decreased life expectancy. Lack of progress in improving treatment outcomes has been attributed toExpand
  • 448
  • 28
Support for the involvement of large copy number variants in the pathogenesis of schizophrenia.
We investigated the involvement of rare (<1%) copy number variants (CNVs) in 471 cases of schizophrenia and 2792 controls that had been genotyped using the Affymetrix GeneChip 500K Mapping Array.Expand
  • 389
  • 20
Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia.
Copy number variations (CNVs) account for a substantial proportion of human genomic variation, and have been shown to cause neurodevelopmental disorders. We sought to determine the relevance of CNVsExpand
  • 368
  • 18
Microduplications of 16p11.2 are Associated with Schizophrenia
Recurrent microdeletions and microduplications of a 600-kb genomic region of chromosome 16p11.2 have been implicated in childhood-onset developmental disorders. We report the association of 16p11.2Expand
  • 601
  • 14
Genome-wide association study identifies 30 Loci Associated with Bipolar Disorder
Bipolar disorder is a highly heritable psychiatric disorder that features episodes of mania and depression. We performed the largest genome-wide association study to date, including 20,352 cases andExpand
  • 210
  • 14
CNVs in neuropsychiatric disorders.
  • G. Kirov
  • Biology, Medicine
  • Human molecular genetics
  • 30 June 2015
Over the last few years at least 11 copy number variations (CNVs) have been shown convincingly to increase risk to developing schizophrenia: deletions at 1q21.1, NRXN1, 3q29, 15q11.2, 15q13.3 andExpand
  • 89
  • 9
Neurexin 1 (NRXN1) deletions in schizophrenia.
Over the last 2 years, several reports have suggested that submicroscopic chromosomal deletions that disrupt the gene neurexin 1 (NRXN1) increase the risk of developing schizophrenia. In thisExpand
  • 210
  • 8
Finding schizophrenia genes.
Genetic epidemiological studies suggest that individual variation in susceptibility to schizophrenia is largely genetic, reflecting alleles of moderate to small effect in multiple genes. MolecularExpand
  • 128
  • 7