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- Publications
- Influence
Subtypes of Pancreatic Ductal Adenocarcinoma and Their Differing Responses to Therapy
- E. Collisson, A. Sadanandam, +15 authors J. Gray
- Biology, Medicine
- Nature Medicine
- 1 April 2011
Pancreatic ductal adenocarcinoma (PDA) is a lethal disease. Overall survival is typically 6 months from diagnosis. Numerous phase 3 trials of agents effective in other malignancies have failed to… Expand
Control of somatic tissue differentiation by the long non-coding RNA TINCR
- M. Kretz, Z. Siprashvili, +17 authors P. Khavari
- Biology, Medicine
- Nature
- 10 January 2013
Several of the thousands of human long non-coding RNAs (lncRNAs) have been functionally characterized; however, potential roles for lncRNAs in somatic tissue differentiation remain poorly understood.… Expand
Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression.
Chronic pancreatitis is a well-known risk factor for pancreatic ductal adenocarcinoma (PDA) development in humans, and inflammation promotes PDA initiation and progression in mouse models of the… Expand
Aberrant expression of MUC5AC and MUC6 gastric mucins and sialyl Tn antigen in intraepithelial neoplasms of the pancreas.
BACKGROUND & AIMS
It has recently been suggested that infiltrating adenocarcinoma of the pancreas arises from histologically well-defined precursor ductal lesions called pancreatic intraepithelial… Expand
The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma
- G. V. Figura, A. Fukuda, +12 authors M. Hebrok
- Biology, Medicine
- Nature Cell Biology
- 1 March 2014
Pancreatic ductal adenocarcinoma (PDA) develops through distinct precursor lesions, including pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasia (IPMN).… Expand
Ampullary Region Carcinomas: Definition and Site Specific Classification With Delineation of Four Clinicopathologically and Prognostically Distinct Subsets in an Analysis of 249 Cases
- V. Adsay, N. Ohike, +14 authors M. Goodman
- Medicine
- The American journal of surgical pathology
- 1 November 2012
Ampullary (AMP) carcinomas comprise a heterogenous group of cancers lacking adequate subcategorization. In the present study, 249 strictly defined primary AMP carcinomas (ACs) identified in 1469… Expand
Design and validation of the biliary atresia research consortium histologic assessment system for cholestasis in infancy.
- P. Russo, J. Magee, +11 authors R. Sokol
- Medicine
- Clinical gastroenterology and hepatology : the…
- 1 April 2011
BACKGROUND & AIMS
Pathologists participating in the National Institutes of Health-sponsored Biliary Atresia Research Consortium (BARC) developed and then evaluated a standardized system for… Expand
Morphologic Findings in Progressive Familial Intrahepatic Cholestasis 2 (PFIC2): Correlation With Genetic and Immunohistochemical Studies
- Kimberley J Evason, K. Bove, +7 authors G. Kim
- Biology, Medicine
- The American journal of surgical pathology
- 1 May 2011
Progressive familial intrahepatic cholestasis, type 2 (PFIC2), characterized by cholestasis in infancy that may progress to cirrhosis, is caused by mutation in ABCB11, which encodes bile salt export… Expand
Stabilization of beta-catenin induces pancreas tumor formation.
BACKGROUND & AIMS
beta-Catenin signaling within the canonical Wnt pathway is essential for pancreas development. However, the pathway is normally down-regulated in the adult organ. Increased… Expand
The alternative lengthening of telomere phenotype is significantly associated with loss of ATRX expression in high-grade pediatric and adult astrocytomas: a multi-institutional study of 214…
- M. Abedalthagafi, J. Phillips, +11 authors A. Perry
- Biology, Medicine
- Modern Pathology
- 14 June 2013
Loss-of-function of alpha thalassemia/mental retardation syndrome X-linked (ATRX) protein leads to a phenotype called alternative lengthening of telomeres (ALT) in some tumors. High-grade… Expand
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