G. Keusch

Publications441
h-index62
Citations14,439
Highly Influential Citations418
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The intolerable burden of malaria: a new look at the numbers.
Quinolone antibiotics induce Shiga toxin-encoding bacteriophages, toxin production, and death in mice.
TLDR
Treatment of human STEC infection with bacteriophage-inducing antibiotics, such as fluoroquinolones, may have significant adverse clinical consequences and that fluoroquolone antibiotics may enhance the movement of virulence factors in vivo.
Shiga toxin: biochemistry, genetics, mode of action, and role in pathogenesis.
TLDR
The definitive description of this organism was provided by Kiyoshi Shiga following an extensive dysentery epidemic in Japan in 1896 (Shiga 1898), and in 1900 Flexner concluded that shigellosis was due to a “toxic agent rather than to an infection per se”.
In vitro encystation of Giardia lamblia: large-scale production of in vitro cysts and strain and clone differences in encystation efficiency.
TLDR
A method for obtaining large numbers of Giardia lamblia cysts in vitro developed based on modification of earlier methods of in vitro encystation resulted in production of cysts that were shown to be viable by fluorogenic dye staining and ability to excyst.
Nucleotide sequence of the Shiga-like toxin genes of Escherichia coli.
TLDR
The nucleotide sequence of the sltA and sltB genes that encode the Shiga-like toxin (SLT) produced by Escherichia coli phage H19B is determined, providing evidence for the hypothesis that certain prokaryotic toxins may be evolutionarily related to eukaryotic enzymes.
Pathogenesis of shigella diarrhea. XI. Isolation of a shigella toxin- binding glycolipid from rabbit jejunum and HeLa cells and its identification as globotriaosylceramide
TLDR
These studies show an identical carbohydrate- specific glycolipid receptor for shigella toxin in gut and in HeLa cells and the possibility that the pilus and toxin B subunit contain homologous sequences.
Sustaining Global Surveillance and Response to Emerging Zoonotic Diseases
TLDR
This report calls for the United States to take the lead, working with global health organizations, to establish a global zoonotic disease surveillance system that better integrates the human and animal health sectors for improved early detection and response.
Vitamin E and respiratory tract infections in elderly nursing home residents: a randomized controlled trial.
CONTEXT Respiratory tract infections are prevalent in elderly individuals, resulting in increased morbidity, mortality, and use of health care services. Vitamin E supplementation has been shown to…
Regulation of the Shiga-like toxin II operon in Escherichia coli
TLDR
The study revealed that the DNA-binding protein H-NS has a regulatory impact on both bacteriophage-mediated SLT-II synthesis and the activity of the slt-II promoter of plasmid pADR-28.
Environmental enteric dysfunction: pathogenesis, diagnosis, and clinical consequences.
TLDR
A historical approach is provided and recommendations to define and validate a working clinical diagnosis and to guide critical research in this area to effectively proceed are provided.
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