G. Kennedy

Publications194
h-index32
Citations4,462
Highly Influential Citations275
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The Toxicology of Perfluorooctanoate
ABSTRACT PFOA is a peroxisome proliferator (PPAR agonist) and exerts morphological and biochemical effects characteristic of PPAR agonists. These effects include increased β-oxidation of fatty acids,… Expand
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Toxicity of ammonium perfluorooctanoate in male cynomolgus monkeys after oral dosing for 6 months.
Ammonium perfluorooctanoate (APFO) is a processing aid in the production of fluoropolymers that has been shown to have a long half-life in human blood. To understand the potential toxicological… Expand
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Pharmacokinetics of perfluorooctanoate in cynomolgus monkeys.
The pharmacokinetics of perfluorooctanoate (PFOA) in cynomolgus monkeys were studied in a six-month oral capsule dosing study of ammonium perfluorooctanoate (APFO) and in a single-dose iv study. In… Expand
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The reproductive toxicology of ammonium perfluorooctanoate (APFO) in the rat.
Ammonium perfluorooctanoate (APFO) is a surfactant used primarily as an aid in processing various fluoropolymers. Many toxicology and epidemiological studies have been conducted with APFO; however,… Expand
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13‐Week Dietary Toxicity Study of Ammonium Perfluorooctanoate (APFO) in Male Rats
Ammonium perfluorooctanoate is a perfluorinated carboxylate that is used commercially as a processing aid in the production of fluorinated polymers. Perfluorooctanoate (PFOA) has been found in human… Expand
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Comparative responses of rats and mice exposed to linear/branched, linear, or branched ammonium perfluorooctanoate (APFO).
The purpose of this study was to compare the toxicity of linear/branched ammonium perfluorooctanoate (APFO) with that of linear and branched APFO. Linear/branched APFO (approximately 80% linear and… Expand
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Renal elimination of perfluorocarboxylates (PFCAs).
Sex-, species-, and chain length-dependent renal elimination is the hallmark of mammalian elimination of perfluorocarboxylates (PFCAs) and has been extensively studied for almost 30 years. In this… Expand
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Absorption, distribution, metabolism, and elimination of 8-2 fluorotelomer alcohol in the rat.
The absorption, distribution, metabolism, and elimination of [3-14C] 8-2 fluorotelomer alcohol (8-2 FTOH, C7F1514CF2CH2CH2OH) following a single oral dose at 5 and 125 mg/kg in male and female rats… Expand
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Absorption, Distribution, and Excretion of Ammonium Perfluorooctanoate (APFO) After Oral Administration to Various Species
Male and female mice, rats, hamsters, and rabbits were treated with a single oral dose of 14C-ammonium perfluorooctanoate (APFO), and the excretion and tissue distributions were followed for 120 h… Expand
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Perfluoroalkyl acids and related chemistries--toxicokinetics and modes of action.
The perfluoroalkyl acid salts (both carboxylates and sulfonates, hereafter designated as PFAAs) and their derivatives are important chemicals that have numerous consumer and industrial applications.… Expand
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