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The Toxicology of Perfluorooctanoate
ABSTRACT PFOA is a peroxisome proliferator (PPAR agonist) and exerts morphological and biochemical effects characteristic of PPAR agonists. These effects include increased β-oxidation of fatty acids,Expand
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Toxicity of ammonium perfluorooctanoate in male cynomolgus monkeys after oral dosing for 6 months.
Ammonium perfluorooctanoate (APFO) is a processing aid in the production of fluoropolymers that has been shown to have a long half-life in human blood. To understand the potential toxicologicalExpand
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Pharmacokinetics of perfluorooctanoate in cynomolgus monkeys.
The pharmacokinetics of perfluorooctanoate (PFOA) in cynomolgus monkeys were studied in a six-month oral capsule dosing study of ammonium perfluorooctanoate (APFO) and in a single-dose iv study. InExpand
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The reproductive toxicology of ammonium perfluorooctanoate (APFO) in the rat.
Ammonium perfluorooctanoate (APFO) is a surfactant used primarily as an aid in processing various fluoropolymers. Many toxicology and epidemiological studies have been conducted with APFO; however,Expand
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13‐Week Dietary Toxicity Study of Ammonium Perfluorooctanoate (APFO) in Male Rats
Ammonium perfluorooctanoate is a perfluorinated carboxylate that is used commercially as a processing aid in the production of fluorinated polymers. Perfluorooctanoate (PFOA) has been found in humanExpand
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Comparative responses of rats and mice exposed to linear/branched, linear, or branched ammonium perfluorooctanoate (APFO).
The purpose of this study was to compare the toxicity of linear/branched ammonium perfluorooctanoate (APFO) with that of linear and branched APFO. Linear/branched APFO (approximately 80% linear andExpand
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Renal elimination of perfluorocarboxylates (PFCAs).
Sex-, species-, and chain length-dependent renal elimination is the hallmark of mammalian elimination of perfluorocarboxylates (PFCAs) and has been extensively studied for almost 30 years. In thisExpand
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Absorption, distribution, metabolism, and elimination of 8-2 fluorotelomer alcohol in the rat.
The absorption, distribution, metabolism, and elimination of [3-14C] 8-2 fluorotelomer alcohol (8-2 FTOH, C7F1514CF2CH2CH2OH) following a single oral dose at 5 and 125 mg/kg in male and female ratsExpand
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Absorption, Distribution, and Excretion of Ammonium Perfluorooctanoate (APFO) After Oral Administration to Various Species
Male and female mice, rats, hamsters, and rabbits were treated with a single oral dose of 14C-ammonium perfluorooctanoate (APFO), and the excretion and tissue distributions were followed for 120 hExpand
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Perfluoroalkyl acids and related chemistries--toxicokinetics and modes of action.
The perfluoroalkyl acid salts (both carboxylates and sulfonates, hereafter designated as PFAAs) and their derivatives are important chemicals that have numerous consumer and industrial applications.Expand
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