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A monoclonal antibody (NKI-L16) directed against a unique epitope on the alpha-chain of human leukocyte function-associated antigen 1 induces homotypic cell-cell interactions.
TLDR
A unique antibody reacting with the alpha-chain of the human leukocyte function-associated Ag-1 is described, which stimulates homotypic cell-cell interactions in a manner very similar to 12-O-tetradecanoyl-phorbol-13-acetate (TPA), in contrast to other anti-LFA-1 mAb which inhibit cell aggregation.
Activation of LFA-1 through a Ca2(+)-dependent epitope stimulates lymphocyte adhesion
TLDR
Three distinct forms of LFA-1 are proposed: an inactive form, which does not, or only partially exposes the NKI-L16 epitope, found on resting cells; an intermediate form, expressed by mature or previously activated cells; and an active form, capable of high affinity ligand binding, obtained after specific triggering of a lymphocyte through the TCR/CD3 complex, by PMA, or by binding of NKI -L16 antibodies.
Characterization of monoclonal antibodies against cell surface molecules associated with cytotoxic activity of natural and activated killer cells and cloned CTL lines.
TLDR
The results presented here indicate that the antigens recognized by SPV-L1 and SPv-L5 are involved in various cytotoxic reactions.
Biochemical and functional characteristics of the human leukocyte membrane antigen family LFA‐1, Mo‐1 and p!50,95
TLDR
The results suggest that the differences in these biological functions of LFA‐1 and Mo‐1 may be related to their different a subunits, which may recognize specific counter structures.
On the mode of action of LFA-1.
TLDR
It is shown that LFA-1-dependent cell adhesion is a dynamic process in which ligand-binding affinity is regulated by intramolecular changes in L FA-1, which is controlled by other lymphocyte surface structures, notably CD2 and CD3.
Characterization of melanoma‐associated surface antigens involved in the adhesion and motility of human melanoma cells
TLDR
Interestingly, the antigen detected by AMF‐7 was strongly associated with the adhesion and cytoplasmic spreading of melanoma cells to plastic surfaces and monolayers of vascular endothelial cells.
Identification of a widely distributed 90-kDa glycoprotein that is homologous to the Hermes-1 human lymphocyte homing receptor.
TLDR
Results indicate that the 90-kDa glycoprotein homologues of the Hermes-1 human lymphocyte homing receptor are expressed on hemopoietic tissues as well as on a number of nonhemopoetic tissues and tumor cell lines.
Immunologic studies with LFA-1- and Mo1-deficient lymphocytes from a patient with recurrent bacterial infections.
TLDR
All lymphocyte functions, including killer (K), natural killer (NK), cytotoxic T cell activity, helper activity for in vitro immunoglobulin (Ig) production by normal B cells, and PHA-induced proliferation were inhibitable by anti-LFA-1 monoclonal antibodies.
Purification and N-terminal amino acid sequence of the human T cell surface antigen T8.
TLDR
The development of a purification scheme that will permit the accumulation of larger quantities of T8 is described, and it is observed that the protein existed as two bands of Mr 33 and 34 kilodaltons after SDS-PAGE analysis.
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