• Publications
  • Influence
The Cellular Trafficking and Zinc Dependence of Secretory and Lysosomal Sphingomyelinase, Two Products of the Acid Sphingomyelinase Gene*
The acid sphingomyelinase (ASM) gene, which has been implicated in ceramide-mediated cell signaling and atherogenesis, gives rise to both lysosomal SMase (L-SMase), which is reportedlyExpand
  • 217
  • 14
Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase.
  • K. Diener, X. Wang, +5 authors Z. Yao
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2 September 1997
The c-Jun N-terminal kinase (JNK), or stress-activated protein kinase plays a crucial role in cellular responses stimulated by environmental stress and proinflammatory cytokines. However, theExpand
  • 132
  • 11
Human casein kinase Iδ phosphorylation of human circadian clock proteins period 1 and 2
Casein kinase Iϵ (CKIϵ), a central component of the circadian clock, interacts with and phosphorylates human period protein 1 (hPER1) [Keesler, G.A. et al. (2000) NeuroReport 5, 951–955]. A mutationExpand
  • 129
  • 6
Identification of stathmin as a novel substrate for p38 delta.
p38 mitogen-activated protein kinases (MAPK) are a family of kinases that are activated by cellular stresses and inflammatory cytokines. Although there are many similarities shared by the isoforms ofExpand
  • 80
  • 5
Purification and activation of recombinant p38 isoforms alpha, beta, gamma, and delta.
p38 is a proline-directed serine/threonine kinase that is activated by inflammatory cytokines and cellular stress. At present, four isoforms of p38 have been identified and termed alpha, beta, gamma,Expand
  • 34
  • 3
Evidence That the Initial Up-regulation of Phosphatidylcholine Biosynthesis in Free Cholesterol-loaded Macrophages Is an Adaptive Response That Prevents Cholesterol-induced Cellular Necrosis
Macrophages in atherosclerotic lesions accumulate free cholesterol (FC) as well as cholesteryl ester and appear to have high rates of phospholipid (PL) synthesis and increased PL mass. Previous shortExpand
  • 98
  • 2
Phosphorylation and destabilization of human period I clock protein by human casein kinase Iε
Period (PER), a central component of the circadian clock in Drosophila, undergoes daily oscillation in abundance and phosphorylation state. Here we report that human casein kinase lε (hCKIε) canExpand
  • 122
  • 2
Regulation of partitioned sterol biosynthesis in Saccharomyces cerevisiae.
Using yeast strains with null mutations in structural genes which encode delta-aminolevulinic acid synthetase (HEM1), isozymes of 3-hydroxy-3-methylglutaryl coenzyme A (HMG1 and HMG2), squaleneExpand
  • 47
  • 2
  • PDF
Purification and Activation of Recombinant p38 Isoforms α, β, γ, and δ
Abstract p38 is a proline-directed serine/threonine kinase that is activated by inflammatory cytokines and cellular stress. At present, four isoforms of p38 have been identified and termed α, β, γ,Expand
  • 62
  • 1
Cholesterol loading of macrophages leads to marked enhancement of native lipoprotein(a) and apoprotein(a) internalization and degradation.
Lipoprotein(a) levels in the plasma are strongly correlated with atherosclerotic coronary artery disease. Although the mechanism of this effect is not known, the interaction of lipoprotein(a) withExpand
  • 54
  • 1