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Antagonism of AMPA receptors produces anxiolytic-like behavior in rodents: Effects of GYKI 52466 and its novel analogues
RationaleAlthough emerging number of data supports the role of glutamate receptors and the potential of their antagonists in anxiety disorders, the involvement ofExpand
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The effects of AMPA receptor antagonists in models of stroke and neurodegeneration.
Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists have been shown to have neuroprotective effects in stroke models and although clinical trials with some agents areExpand
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Neuroprotective and anticonvulsant effects of EGIS‐8332, a non‐competitive AMPA receptor antagonist, in a range of animal models
Blockade of AMPA (α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid) receptors is a good treatment option for a variety of central nervous system disorders. The present study evaluated theExpand
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New non competitive AMPA antagonists.
New halogen atom substituted 2,3-benzodiazepine derivatives condensed with an azole ring on the seven membered part of the ring system of type 3 and 4 as well as 5 and 6 were synthesized. It wasExpand
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AMPA receptor antagonists, GYKI 52466 and NBQX, do not block the induction of long-term potentiation at therapeutically relevant concentrations
The involvement of alpha-amino-3-hydroxy-5-methylizoxazole-4-propionic acid (AMPA) receptors in induction of long-term potentiation (LTP) was examined in rat hippocampal slice preparation. UsingExpand
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A novel GABA(A) alpha 5 receptor inhibitor with therapeutic potential.
Novel 2,3-benzodiazepine and related isoquinoline derivatives, substituted at position 1 with a 2-benzothiophenyl moiety, were synthesized to produce compounds that potently inhibited the action ofExpand
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Deramciclane improves object recognition in rats: Potential role of NMDA receptors
The cognition-enhancing properties of deramciclane (N,N-dimethyl-2-([(1R,4R,6S)-1,7,7-trimethyl-6-phenyl-6-bicyclo[2.2.1]heptanyl]oxy)ethanamine) and memantineExpand
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Comparison of the AMPA Antagonist Action of New 2,3-Benzodiazepines in Vitro and Their Neuroprotective Effects in Vivo
AbstractPurpose. AMPA receptor-mediated excitotoxicity is thought to be a critical process in diseases accompanied by neuronal cell loss following a hypoxic/anoxic state of the central nervousExpand
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Excitatory amino acids and synaptic transmission in embryonic rat brainstem motoneurons in organotypic culture
We used brainstem motoneurons recorded in organotypic slice co‐cultures maintained for more than 18 days in vitro, together with multibarrel ionophoretic applications of glutamate receptor agonistsExpand
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Interactions of allosteric modulators of AMPA/kainate receptors on spreading depression in the chicken retina
The functional role of AMPA and kainate receptors in spreading depression (SD) was investigated in the isolated chicken retina. Competitive (NBQX) and non-competitive (GYKI 52466, GYKI 53405 and GYKIExpand
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