• Publications
  • Influence
The adenylate cyclase-cAMP-protein kinase A pathway and regulation of the immune response.
  • G. Kammer
  • Biology, Medicine
  • Immunology today
  • 1988
Abstract Adenylate cyclase, the second messenger cAMP and cAMP-dependent protein kinase A are important mediators in determining the response of a cell to external stimuli. As Gary Kammer reviewsExpand
  • 509
  • 11
Psoriatic arthritis: a clinical, immunologic and HLA study of 100 patients.
  • 172
  • 6
Molecular Basis of Deficient IL-2 Production in T Cells from Patients with Systemic Lupus Erythematosus1
Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease characterized by diverse cellular and biochemical aberrations, including decreased production of IL-2. Here we show thatExpand
  • 177
  • 6
  • PDF
B cells from patients with systemic lupus erythematosus display abnormal antigen receptor-mediated early signal transduction events.
To understand the molecular mechanisms that are responsible for the B cell overactivity that is observed in patients with SLE, we have conducted experiments in which the surface immunoglobulinExpand
  • 229
  • 4
  • PDF
Trichostatin A reverses skewed expression of CD154, interleukin-10, and interferon-γ gene and protein expression in lupus T cells
In systemic lupus erythematosus (SLE), T helper cells exhibit increased and prolonged expression of cell-surface CD40 ligand (CD154), spontaneously overproduce interleukin-10 (IL-10), butExpand
  • 161
  • 4
Fc epsilon receptor type I gamma chain replaces the deficient T cell receptor zeta chain in T cells of patients with systemic lupus erythematosus.
OBJECTIVE T cells from the majority of patients with systemic lupus erythematosus (SLE) express significantly lower levels of T cell receptor zeta chain, a critical signaling molecule. However,Expand
  • 157
  • 4
Abnormal T cell signal transduction in systemic lupus erythematosus.
Systemic lupus erythematosus (SLE) is an acute and chronic autoimmune disease of indeterminate etiology characterized by protean clinical symptoms and signs. Although this syndrome can occur inExpand
  • 144
  • 3
Treatment of primary Sjögren's syndrome with low-dose human interferon alfa administered by the oromucosal route: combined phase III results.
OBJECTIVE This study tested the safety and efficacy of human interferon (IFN) alfa for treatment of salivary hypofunction and dry mouth symptoms in primary Sjögren's syndrome patients. METHODSExpand
  • 144
  • 3
  • PDF
T cell signaling abnormalities in systemic lupus erythematosus are associated with increased mutations/polymorphisms and splice variants of T cell receptor zeta chain messenger RNA.
OBJECTIVE T cells from patients with systemic lupus erythematosus (SLE) display antigen receptor-mediated signaling aberrations associated with defective T cell receptor (TCR) zeta chain protein andExpand
  • 68
  • 3
Polymorphisms/mutations of TCR-zeta-chain promoter and 3' untranslated region and selective expression of TCR zeta-chain with an alternatively spliced 3' untranslated region in patients with systemic
A vast majority of systemic lupus erythematosus (SLE) patients display decreased expression of TCR zeta-chain mRNA, a critical signaling molecule implicated in the selection of the TCR repertoire andExpand
  • 70
  • 3