• Publications
  • Influence
In vivo relationship between horny layer reservoir effect and percutaneous absorption in human and rat.
The in vivo relationship between the reservoir effect of the stratum corneum and the percutaneous absorption was established in both human volunteers and hairless rats, and the molecular reservoir of the horny layer may well be situated within the interlayer spaces. Expand
Percutaneous absorption of p‐phenylene diamine during an actual hair dyeing procedure
A five‐ to ten‐fold decrease in its penetration was observed by protecting the scalp with clay before applying the dyeing composition, and the dose excretion for p‐phenylene diamine as measured was comparable to that found by other authors who made use of radioactively labelled material. Expand
Mutagenicity of aminonitrophenol compounds in Salmonella typhimurium: a study of structural‐activity relationships
The results on mutagenic and non‐mutagenic aminonitrophenols and their derivatives suggest that the occurrence of mutagenics activity among these compounds depends on the nature of the substituent chemical groups and their position in the molecular structure of the compounds. Expand
Structure-activity relationship within a series of m-diaminobenzene derivatives.
Depending on the size of the substituting alkyl group at the C1 position of 2,4-diaminoalkylbenzene, a decline and loss of mutagenic activity was observed. Expand
Studies on the mutagenicity of p-phenylenediamine in Salmonella typhimurium. Presence of PCB's in rat-liver microsomal fraction induced by Aroclor.
The mutagenicity of fresh solutions of p-phenylenediamine and Aroclor 1254 was investigated and, in the absence of metabolic activation, as well as in the presence of uninduced rat-liver homogenate, PPD was not mutagenic in the strains used. Expand
Structure--activity relationships within a series of 2,4-diaminoalkoxybenzene compounds.
The relative response of the various strains suggests that 2,4-diaminoalkoxybenzenes induce frameshift mutations but not base-pair substitutions, as shown in strains TA98, TA1538 and in some cases TA1537. Expand
Relationships between the Chemical Structure and Mutagenic Activity of Monocyclic Aromatic Amines
Hundreds of compounds have now been tested for mutagenic activity in many laboratories throughout the world. Mutagenicity tests are performed to validate a variety of assay systems and to contributeExpand
Structure-activity relationships of aromatic amines in the Ames Salmonella typhimurium assay.
The author tried in a somewhat limited work to quantitatively correlate the electronic and steric intramolecular interactions of substituents on the amino group (influencing the enzymatic reactionsExpand
Studies on the mutagenicity of resorcinol and hydroxy-3-(p-amino)anilino-6,N-[(p-amino)phenol]benzoquinone-monoimine-1,4 in Salmonella typhimurium.
The nuclear magnetic resonance spectrum of the reaction product of p-phenylenediamine and resorcinol was recorded and is in agreement with its chemical structure. Expand
Experimental studies on a new hair dyeing ingredient 2-(2', 4'-diaminophenoxy) ethanol : lack of genotoxic properties.
  • G. Kalopissis
  • Chemistry, Medicine
  • Toxicological European research. Recherche…
  • 1 July 1981
A benzene metadiamine derivative, 2-(2', 4' diaminophenoxy) ethanol proved to be interesting in hairdyeing and its genotoxicity was investigated in various tests, which indicates a correlation among the battery of tests. Expand