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Metabolic engineering tanshinone biosynthetic pathway in Salvia miltiorrhiza hairy root cultures.
This is the first report on enhancement of tanshinone content and antioxidant activity achieved through metabolic engineering of hairy roots by push-pull strategy in S. miltiorrhiza. Expand
Risk assessment, formation, and mitigation of dietary acrylamide: current status and future prospects.
  • Yi Xu, Bo Cui, +4 authors Jianxin Shi
  • Chemistry, Medicine
  • Food and chemical toxicology : an international…
  • 1 July 2014
The state-of-the-art understanding of AA is addressed, focusing on risk assessment, mechanism of formation and strategies of mitigation in foods, and the potential application of omics to AA risk assessment is discussed. Expand
A Review of Dietary Polyphenol-Plasma Protein Interactions: Characterization, Influence on the Bioactivity, and Structure-Affinity Relationship
  • J. Xiao, G. Kai
  • Chemistry, Medicine
  • Critical reviews in food science and nutrition
  • 1 January 2012
An overview of the research reports on the characterization, influence on the bioactivity, and the structure-affinity relationship for studying the affinities between polyphenols and plasma proteins is given. Expand
Increased accumulation of the cardio-cerebrovascular disease treatment drug tanshinone in Salvia miltiorrhiza hairy roots by the enzymes 3-hydroxy-3-methylglutaryl CoA reductase and
Key enzyme genes SmHMGR and SmDXR involved in the tanshinone biosynthetic pathway were introduced into Salvia miltiorrhiza (Sm) hairy roots to enhance tANShinone production to provide a useful strategy to improve tansinone content as well as other natural active products by combination of genetic engineering with elicitors. Expand
COVID-19: Pathogenesis, cytokine storm and therapeutic potential of interferons
The current research suggests that few groups of patients with COVID-19 might have a cytokine storm syndrome, and identification and treatment of hyperinflammation using existing, approved therapies with proven safety profiles to address the immediate need to reduce the rising mortality. Expand
Molecular cloning, characterization and expression analysis of a new gene encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase from Salvia miltiorrhiza
The expression of SmHMGR could be up-regulated by salicylic acid (SA) and methyl jasmonate (MeJA), suggesting that SmHM GR was elicitor-responsive, and will be helpful to understand more about the role of HMGR involved in the tanshinones biosynthesis at the molecular level. Expand
A Review on Structure–Activity Relationship of Dietary Polyphenols Inhibiting α-Amylase
The aim of this review is to give an overview of the research reports on the structure–activity relationship of polyphenols inhibiting α-amylase. Expand
Co-expression of AaPMT and AaTRI effectively enhances the yields of tropane alkaloids in Anisodus acutangulus hairy roots
Co-expression of AaPMT and AaTRI genes in A. acutangulus hairy roots significantly improved the yields of TA and showed higher antioxidant activity than control because of higher total TA content, which is the first report on simultaneous introduction of PMT and TRI genes into TA-producing plant by biotechnological approaches. Expand
Engineering tropane biosynthetic pathway in Hyoscyamus niger hairy root cultures.
  • L. Zhang, R. Ding, +11 authors K. Tang
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 27 April 2004
It is concluded that transgenic plants Harboring both pmt and h6h possessed an increased flux in the tropane alkaloid biosynthetic pathway that enhanced scopolamine yield, which was more efficient than plants harboring only one of the two genes. Expand
Development of the visual loop-mediated isothermal amplification assays for seven genetically modified maize events and their application in practical samples analysis.
The results indicated that the established event-specific visual LAMP assays are more convenient, rapid, and low-cost for GM maize routine analysis. Expand