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Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus.
- A. Galvez, G. Giménez-Gallego, +4 authors M. L. García
- Chemistry, MedicineThe Journal of biological chemistry
- 5 July 1990
Data suggest that IbTX interacts at a distinct site on the channel and modulates ChTX binding by an allosteric mechanism, which defines a new class of peptidyl inhibitor of PK,Ca with unique properties that make it useful for investigating the characteristics of this channel in target tissues.
Functional Expression of Drosophila para Sodium Channels Modulation by the Membrane Protein TipE and Toxin Pharmacology
The results suggest that the selective toxicity of pyrethroid insecticides is due at least in part to the greater affinity of pyrethroids for insect sodium channels than for mammalian sodium channels.
Functional colocalization of calcium and calcium-gated potassium channels in control of transmitter release
- R. Robitaille, Maria L. Garcia, G. Kaczorowski, Milton P. Chariton
- Medicine, ChemistryNeuron
- 1 October 1993
It is concluded that gKca channels are strategically clustered at the neurotransmitter release sites, where they can be quickly activated by Ca2+ entering the terminal.
High-conductance calcium-activated potassium channels; Structure, pharmacology, and function
- G. Kaczorowski, H. Knaus, R. Leonard, O. McManus, Maria L. Garcia
- Chemistry, MedicineJournal of bioenergetics and biomembranes
- 1 June 1996
Potent, selective maxi-K channel effectors (both agonists and blockers) of low molecular weight have been identified from natural product sources and can be used to anatomically map maxi"-K channel expression, and to study the physiologic role of maxi -K channels in various tissues.
Contribution of the tetrodotoxin-resistant voltage-gated sodium channel NaV1.9 to sensory transmission and nociceptive behavior.
- B. Priest, B. Murphy, +10 authors W. Martin
- Biology, MedicineProceedings of the National Academy of Sciences…
- 28 June 2005
The results suggest that inflammatory mediators modify the function of NaV1.9 to maintain inflammation-induced hyperalgesia and contribute to the persistent thermal hypersensitivity and spontaneous pain behavior after peripheral inflammation.
Distribution of high-conductance Ca(2+)-activated K+ channels in rat brain: targeting to axons and nerve terminals
- H. Knaus, C. Schwarzer, +7 authors G. Sperk
- Biology, MedicineThe Journal of neuroscience : the official…
- 1 February 1996
The expression pattern of Slo is consistent with its targeting into a presynaptic compartment, which implies an important role in neural transmission.
Purification, characterization, and biosynthesis of margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels.
- M. Garcia-Calvo, R. Leonard, +4 authors M. L. García
- Medicine, ChemistryThe Journal of biological chemistry
- 5 September 1993
A novel peptidyl inhibitor of K+ channels has been purified to homogeneity from venom of the new world scorpion Centruroides margaritatus and displays significant sequence homology with previously identified K+ channel inhibitors.
ProTx-II, a Selective Inhibitor of NaV1.7 Sodium Channels, Blocks Action Potential Propagation in Nociceptors
- W. Schmalhofer, J. Calhoun, +7 authors B. Priest
- Chemistry, MedicineMolecular Pharmacology
- 1 November 2008
The 125I-ProTx-II binding assay, described here, offers a new tool in the search for novel NaV1.7-selective channel blockers, suggesting that ProTx- II binds to a novel site, which may be more conducive to conferring subtype selectivity than the site occupied by traditional local anesthetics and anticonvulsants.
Primary sequence and immunological characterization of beta-subunit of high conductance Ca(2+)-activated K+ channel from smooth muscle.
- H. Knaus, K. Folander, +4 authors R. Swanson
- Biology, MedicineThe Journal of biological chemistry
- 24 June 1994
The data demonstrate that, in vivo, the high conductance Ca(2+)-activated K+ channel exists as a multimer containing both alpha- andbeta-subunits, and this cDNA represents the first beta-subunit of a potassium channel cloned to date.
Subunit composition of the high conductance calcium-activated potassium channel from smooth muscle, a representative of the mSlo and slowpoke family of potassium channels.
- H. Knaus, M. Garcia-Calvo, G. Kaczorowski, M. L. García
- Medicine, BiologyThe Journal of biological chemistry
- 11 February 1994
The results indicate that the alpha-sub unit of the purified tracheal smooth muscle maxi-K channel is a member of the mSlo family of K+ channels and forms a noncovalent complex with a beta-subunit.