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SPDEF regulates goblet cell hyperplasia in the airway epithelium.
Mouse SAM pointed domain-containing ETS transcription factor (SPDEF) mRNA and protein were detected in subsets of epithelial cells lining the trachea, bronchi, and tracheal glands, and expression was increased at sites of goblet cell hyperplasia caused by IL-13 and dust mite allergen in a process that was dependent upon STAT-6. Expand
Preseasonal treatment with either omalizumab or an inhaled corticosteroid boost to prevent fall asthma exacerbations.
Adding omalizumab before return to school to ongoing guidelines-based care among inner-city youth reduces fall asthma exacerbations, particularly among those with a recent exacerbation. Expand
Influence of dog ownership and high endotoxin on wheezing and atopy during infancy.
A home environment with many dogs and high levels of endotoxin may be conducive to reduced wheeze in infancy, and pet ownership or endotoxin did not independently modify aeroallergen sensitization or wheezing during infancy. Expand
Comparison of anthropometric measures of obesity in childhood allergic asthma: central obesity is most relevant.
Measures of central obesity are more associated with the presence of asthma and asthma severity in children with allergic rhinitis when compared with standard BMI measures. Expand
Diesel exhaust particle induction of IL-17A contributes to severe asthma.
BACKGROUND IL-17A has been implicated in severe forms of asthma. However, the factors that promote IL-17A production during the pathogenesis of severe asthma remain undefined. Diesel exhaustExpand
A Comparison of Proximity and Land Use Regression Traffic Exposure Models and Wheezing in Infants
A land use regression model of exposure to truck and bus traffic resulted in a range of ECAT individually derived for all infants’ homes that may reduce the exposure misclassification that can arise from a proximity model. Expand
High environmental relative moldiness index during infancy as a predictor of asthma at 7 years of age.
Early exposure to molds as measured by ERMI at 1 year ofAge, but not 7 years of age, significantly increased the risk for asthma at 7 yearsOf age, air-conditioning at home reduced the risk of asthma development. Expand
Comparison of measures of marker informativeness for ancestry and admixture mapping
Various methods for selecting ancestry informative SNPs using simulations as well as SNP genotype data from samples of admixed populations are compared and it is shown that the In measure estimates ancestry proportion with lower bias and mean square error. Expand
Optimum predictors of childhood asthma: persistent wheeze or the Asthma Predictive Index?
Both a positive ucAPI and persistent wheeze at age 3 were associated with objectively confirmed asthma at age 7; however, the highest risk was associated with uc API. Expand
Intrinsically defective skin barrier function in children with atopic dermatitis correlates with disease severity.
Skin barrier function as assessed by TEWL is intrinsically compromised inChildren with AD but not in children with other allergic conditions, and the magnitude of skin barrier dysfunction correlates with AD disease severity. Expand