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Synthesis and Antitumor Activity of Cyclopropane Derivatives of Betulinic and Betulonic Acids
TLDR
20, 29-Dihydro-20,29-dibromomethylenebetulinic acid proved to be the most cytotoxic toward human melanoma of the Colo 38 and Bro lines and human ovarian carcinomas of the CaOv line (IC50 10 μM). Expand
Inhibition of protein kinase C by semisynthetic phospholipid plasmanyl-(N-acyl)-ethanolamine, a nontoxic antitumor preparation.
TLDR
The semisynthetic alkyl-phospholipid plasmanyl-(N-acyl)-ethanolamine (PNAEs) with selective antitumor activity inhibited the activity of the protein kinase in a cell-free system in the presence of phosphatidylserine, aprotein kinase C activator. Expand
[Electrolyte content in the blood of animals and potassium ion transport in the erythrocytes under the action of a constant magnetic field].
TLDR
The content of potassium and sodium ions in the blood and plasma of rats exposed to constant magnetic fileds of 1000 and 4500 oersted for varying time was studied and repeated and prolonged chronic exposure did not influence the transport of potassium ions. Expand
Antitumor activity of conjugates of the oncofetal protein alpha‐fetoprotein and phthalocyanines in vitro
TLDR
Experimental data demonstrate that the cytotoxic activity of alpha‐fetoprotein‐phthalocyanine conjugates against three types of tumor cells of various origin is much higher (for aluminium and cobalt complexes more than 1000 and 50 times, respectively) in comparison with phthalocyanines themselves. Expand
Synthesis and cytotoxic activity of α-santonin amino-derivatives
Previously unknown amino-derivatives of the natural sesquiterpene lactone α-santonin were synthesized. The activity of the products against several human tumor-cell lines was studied.
Antitumor activity of conjugates of the oncofetal protein alpha‐fetoprotein and phthalocyanines in vitro
TLDR
Experimental data demonstrate that the cytotoxic activity of alpha‐fetoprotein‐phthalocyanine conjugates against three types of tumor cells of various origin is much higher (for aluminium and cobalt complexes more than 1000 and 50 times, respectively) in comparison with phthalocyanines themselves. Expand
The synthesis of triterpenic amides on the basis of 2,3-seco-1-cyano-19β,28-epoxy-18α-oleane-3-oic acid
Novel 2,3-seco-triterpenic amides were prepared by the interaction of the chloride of 1-cyano-19β,28-epoxy-18α-oleane-3-oic acid with primary amines and synthetic and biogenic amino acids. AExpand
Antiproliferative effect of complexes of platinum (II) with plasmanyl‐(N‐acyl)‐ethanolamine, an inhibitor of protein kinase C
TLDR
The exposure of human melanoma BRO cells in culture simultaneously with cisplatin and PNAE(s) in a molar ratio of 1/100 for 24 h induced a considerable decrease in the ability of these cells to Incorporate [3H]thymidine into DNA. Expand
Epimerization of Hydroxyl Group in Lupan Series Triterpenoids
Two methods of obtaining 3α-betulinic acid and related compounds from their 3β-epimers were studied: the reaction of bimolecular substitution and the stereoselective reduction of 3-ketoderivatives.Expand
[Mathematical description and study of the folic acid cycle reactions].
TLDR
A general description of the folic acid cycle and associate reactions of thymidilate, purines, methionine and serine biosyntheses is presented as a system of differential equations and the adequacy of mathematical models to the experimental data has been demonstrated. Expand
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