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Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein
To study the putative precursor proteins (PreA4(695), PreA4(751), and PreA4(770] of Alzheimer's disease A4 amyloid protein, polyclonal and monoclonal antibodies were raised against a recombinantExpand
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Inhibition of phosphodiesterase 2 increases neuronal cGMP, synaptic plasticity and memory performance
An essential element of the signalling cascade leading to synaptic plasticity is the intracellular second messenger molecule guanosine 3',5'-cyclic monophosphate (cGMP). Using the novel, potent, andExpand
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The Novel α7 Nicotinic Acetylcholine Receptor Agonist N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-7-[2-(methoxy)phenyl]-1-benzofuran-2-carboxamide Improves Working and Recognition Memory in Rodents
The relative contribution of α4β2, α7 and other nicotinic acetylcholine receptor (nAChR) subtypes to the memory enhancing versus the addictive effects of nicotine is the subject of ongoing debate. InExpand
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Randomized, Double-Blind, Placebo-Controlled Study of Encenicline, an α7 Nicotinic Acetylcholine Receptor Agonist, as a Treatment for Cognitive Impairment in Schizophrenia
Encenicline is a novel, selective α7 nicotinic acetylcholine receptor agonist in development for treating cognitive impairment in schizophrenia and Alzheimer’s disease. A phase 2, double-blind,Expand
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Analysis of Flow and Cavitation Phenomena in Diesel Injection Nozzles and Its Effects on Spray and Mixture Formation
In modern DI Diesel engines the raw emissions of NOx and soot are affected, apart from the fuel injection rate, by atomization of the liquid jet and mixing of the fuel with the combustion air.Expand
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Making interoperability persistent : A 3D geo database based on CityGML
We address the modelling and database design of the Berlin 3D geo database as well as the software engineering aspects of the import/export tool. Expand
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Advances in 3D geo-information sciences
During the last decade developments in 3D Geoinformation have made substantial progress. We are about to have a more complete spatial model and understanding of our planet in different scales. Hence,Expand
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Regulation and Expression of the Alzheimer's β/A4 Amyloid Protein Precursor in Health, Disease, and Down's Syndrome a
A four‐ to fivefold overexpression of the gene for the Alzheimer β/A4 amyloid precursor protein (APP) in individuals with Down's Syndrome (DS) appears to be responsible for the fifty year earlierExpand
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Concentration-response relationship of the α7 nicotinic acetylcholine receptor agonist FRM-17874 across multiple in vitro and in vivo assays.
Pharmacological activation of α7 nicotinic acetylcholine receptors (α7 nAChRs) may improve cognition in schizophrenia and Alzheimer's disease. The present studies describe an integratedExpand
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Calculations of Solvation Free Energy through Energy Reweighting from Molecular Mechanics to Quantum Mechanics.
In this work, the solvation free energies of 20 organic molecules from the 4th Statistical Assessment of the Modeling of Proteins and Ligands (SAMPL4) have been calculated. The sampling of phaseExpand
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