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Self-MHC-restricted peptides recognized by an alloreactive T lymphocyte clone.
TLDR
For the first time, self-MHC-restricted peptides are described for a T cell clone that was induced with allo-M HC and reciprocal cross-reactivity suggests that structural features are shared by the two MHC-peptide complexes.
Recognition principle of the TAP transporter disclosed by combinatorial peptide libraries.
TLDR
Combinatorial approaches demonstrate that human TAP is selective, with residues determining the affinity located in distinct regions, and point to the role of the peptide backbone in binding to TAP.
Synthetic lipopeptide analogs of bacterial lipoprotein are potent polyclonal activators for murine B lymphocytes.
TLDR
A series of defined synthetic fragments of a bacterial outer membrane component exhibits a pronounced mitogenic and polyclonally stimulating activity towards B lymphocytes and will be valuable tools for more detailed investigations on the molecular mechanisms of B cell activation.
Synthetic lipopeptides as novel adjuvants.
TLDR
Lipopeptides constitute potent novel immunoadjuvants in mice, rabbits and other species, enhancing markedly the immune response when given in mixture with antigens, and provide a substitute for many conventional adjuvants.
Molecular basis for the recognition of two structurally different major histocompatibility complex/peptide complexes by a single T-cell receptor.
TLDR
The results strongly suggest that adaptation of the T-cell receptor to the different ligand structures, rather than molecular mimicry by the ligands, is the basis for the crossreactivity of 2C.
Decrypting the structure of major histocompatibility complex class I- restricted cytotoxic T lymphocyte epitopes with complex peptide libraries
TLDR
CTL responses to peptide libraries were suppressed when residues were introduced; however, they were augmented when the critical residues for T cell recognition were fixed, suggesting a potential use of the peptideibraries for defining epitope sequences in general.
Peptide libraries in cellular immune recognition.
TLDR
Vertebrates have evolved an adaptive immune system in which specialized white blood cells, the T cells, are trained to recognize proteolytic fragments of viral, bacterial or parasitic antigens in the context of specialized antigen presenting proteins, the major histocompatibility complex (MHC) molecules.
Lipopeptide derivatives of bacterial lipoprotein constitute potent immune adjuvants combined with or covalently coupled to antigen or hapten.
TLDR
The results show that defined lipopeptides are novel immunoadjuvants either combined with or covalently linked to antigens or haptens, and their responses were less pronounced than the response to the conventional heterogeneous hapten-protein conjugate BSA(Dnp).
Lipopeptides of the N-terminus of Escherichia coli lipoprotein: synthesis, mitogenicity and properties in monolayer experiments.
TLDR
This is the first report of monolayer experiments with chemically well defined, synthetic lipopeptide mitogens with the composition of the N-terminus of an important bacterial membrane protein.
Stimulation of human and murine adherent cells by bacterial lipoprotein and synthetic lipopeptide analogues.
TLDR
The results demonstrate that the two novel synthetic lipopeptides are potent stimulators for human monocytes and murine macrophages and may be important for the elucidation of the role of these bacterial surface components in the course of bacterial infections.
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