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Phenolic compounds from Hypericum perforatum.
TLDR
During a re-investigation of phenolic compounds from the dried crude drug material of St. John's wort, 22phenolic compounds were detected by HPLC; 14 of them were quantified using the same system and quercetin-3-O-(2"-O-acetyl)-beta-D-galactoside was identified as a new natural product.
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Flavonoids from Hypericum perforatum show antidepressant activity in the forced swimming test.
TLDR
The validity of a flavonoid fraction obtained from a crude extract of Hypericum perforatum was checked in open field experiments and in the FST after 12 days of daily treatment to exclude false positive results.
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Willow bark extract (BNO1455) and its fractions suppress growth and induce apoptosis in human colon and lung cancer cells.
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Synthesis, cytotoxicity, anti-oxidative and anti-inflammatory activity of chalcones and influence of A-ring modifications on the pharmacological effect.
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Phloroglucinol derivatives from Hypericum empetrifolium with antiproliferative activity on endothelial cells.
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A novel approach to prevent endothelial hyperpermeability: the Crataegus extract WS® 1442 targets the cAMP/Rap1 pathway.
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Revisited anti-inflammatory activity of matricine in vitro: Comparison with chamazulene.
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Dissolution, solubility and cooperativity of phenolic compounds from Hypericum perforatum L. in aqueous systems.
TLDR
Most effective in solubilizing hypericin was hyperoside (hyperin, quercetin 3-O-beta-D-galactoside) which increased the concentration ofhypericin in the water phase up to 400 fold in this model.
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Catechol, a bioactive degradation product of salicortin, reduces TNF-α induced ICAM-1 expression in human endothelial cells.
TLDR
Results indicate catechol as an important bioactive metabolite from salicortin as a result of its ability to reduce the TNF- α induced ICAM-1 expression on human microvascular endothelial cells (HMEC-1).
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Structure-Dependent Deconjugation of Flavonoid Glucuronides by Human β-Glucuronidase - In Vitro and In Silico Analyses.
TLDR
Across the flavonoid subtypes, the C-ring saturation also showed a significant influence on deglucuronidation, whereas A- and B-ring variations within the flavone-7-O-glucuronides did not affect the enzymes' activity.
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