Skip to search formSkip to main contentSkip to account menu
Adriamycin-induced, TNF-α-mediated central nervous system toxicity
View on Elsevier
Adriamycin-induced, TNF-alpha-mediated central nervous system toxicity.
TLDR
It is demonstrated that ADR autofluorescence was detected only in areas of the brain located outside the blood-brain barrier, but a strong tumor necrosis factor alpha immunoreactivity was detected in the cortex and hippocampus of ADR-treated mice, consistent with the notion that TNF is an important mediator by which ADR induces central nervous system (CNS) injury.
View on PubMed
Glutathione elevation by γ‐glutamyl cysteine ethyl ester as a potential therapeutic strategy for preventing oxidative stress in brain mediated by in vivo administration of adriamycin: Implication for…
TLDR
This study test the hypothesis that, by elevating brain levels of GSH, the brain would be protected against oxidative stress in ADR‐injected mice, and results are discussed with regard to potential pharmacological prevention of brain cognitive dysfunction in patients receiving ADR chemotherapy.
View on Wiley
The Nrf2-ARE pathway: a valuable therapeutic target for the treatment of neurodegenerative diseases.
TLDR
This review primarily focuses on recent patents that target Nrf2 overexpression as a promising therapeutic strategy for the treatment of neurodegenerative disorders.
View on PubMed
Free radical mediated oxidative stress and toxic side effects in brain induced by the anti cancer drug adriamycin: Insight into chemobrain
TLDR
A significant increase in levels of protein oxidation and lipid peroxidation and increased expression of MRP1 in brain isolated from mice, 72 h post i.p injection of ADR is demonstrated.
View on Taylor & Francis
Protective effect of quercetin in primary neurons against Abeta(1-42): relevance to Alzheimer's disease.
View on PubMed
Alterations in brain antioxidant enzymes and redox proteomic identification of oxidized brain proteins induced by the anti-cancer drug adriamycin: implications for oxidative stress-mediated chemobrain
View on Elsevier
In vivo administration of D609 leads to protection of subsequently isolated gerbil brain mitochondria subjected to in vitro oxidative stress induced by amyloid beta-peptide and other oxidative…
View on PubMed
Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: Relevance to Alzheimer's disease
View on Elsevier
Increased Alzheimer's disease–like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagy
View on Elsevier
...
...
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License