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EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists.
All available evidence for management of acute and chronic rhinosinusitis with or without nasal polyps in adults and children is analyzed and presented and management schemes based on the evidence are proposed. Expand
New insights into the immunology of chronic obstructive pulmonary disease
The role of autoimmunity (autoantibodies), remodelling, extracellular matrix-derived fragments, impaired innate lung defences, oxidative stress, hypoxia, and dysregulation of microRNAs in the persistence of the pulmonary inflammation despite smoking cessation are discussed. Expand
Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema
Recent data on the role of apoptosis in COPD from both animal models as well as from studies on human subjects will be discussed, with a role for Vascular Endothelial Growth Factor (VEGF) in the induction of apoptoses of structural cells in the lung. Expand
Indirect airway challenges
Indirect bronchial stimuli, in particular exercise, hyperventilation, hypertonic aerosols, as well as adenosine, may reflect more directly the ongoing airway inflammation and are therefore more specific to identify active asthma. Expand
European Position Paper on Rhinosinusitis and Nasal Polyps 2020.
The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 is the update of similar evidence based position papers published in 2005 and 2007 and 2012 and addresses areas not extensively covered in EPOS2012 such as paediatric CRS and sinus surgery. Expand
Accumulation of dendritic cells and increased CCL20 levels in the airways of patients with chronic obstructive pulmonary disease.
- I. Demedts, K. Bracke, +5 authors G. Brusselle
- American journal of respiratory and critical care…
- 15 May 2007
This is the first description of airway infiltration by DC in COPD and interaction between CCL20 and CCR6 provides a possible mechanism for accumulation of DC in the lungs in COPd. Expand
European Position Paper on Rhinosinusitis and Nasal Polyps 2012.
The European Position Paper on Rhinosinusitis and Nasal Polyps 2012 is the update of similar evidence based position papers published in 2005 and 2007 and contains chapters on definitions and classification and management schemes based on the evidence are proposed. Expand
Role of tachykinins in asthma
Sensory nerves containing these peptides are relatively scarce in human airways, but it is becoming increasingly evident that inflammatory cells such as eosinophils, macrophages, lymphocytes, and dendritic cells can produce the tachykinins SP and NKA. Expand
Elevated MMP-12 protein levels in induced sputum from patients with COPD
MMP-12 is markedly increased in induced sputum from patients with stable COPD compared with controls, suggesting a role for MMP- 12 in the development of COPD in smokers. Expand
Cigarette Smoke-Induced Pulmonary Inflammation and Emphysema Are Attenuated in CCR6-Deficient Mice1
Results indicate that the interaction of CCR6 with its ligand MIP-3α contributes to the pathogenesis of CS-induced pulmonary inflammation and emphysema in this murine model of COPD. Expand