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British Hypertension Society guidelines for hypertension management 1999: summary
This article summarises the new British Hypertension Society guidelines for management of hypertension, which have been published in full.1 Since the previous guidelines 2 3 much new evidence hasExpand
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Impaired endothelium-dependent and independent vasodilation in patients with Type 2 (non-insulin-dependent) diabetes mellitus
SummaryThe endothelium plays a pivotal role in modulating the reactivity of vascular smooth muscle through the formation of several vasoactive substances. We examined the effects ofExpand
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Fish oil improves arterial compliance in non-insulin-dependent diabetes mellitus.
In a double-blind, placebo-controlled study we investigated the effects of dietary fish oil supplementation on arterial wall characteristics in 20 patients with non-insulin-dependent diabetesExpand
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Renal and cardiovascular effects of caffeine: a dose-response study.
The effects of increasing oral doses of caffeine (45, 90, 180 and 360 mg) on effective renal plasma flow (ERPF), plasma renin activity (PRA), serum electrolytes, plasma noradrenaline, blood pressureExpand
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Dietary fish oil augments nitric oxide production or release in patients with Type 2 (non-insulin-dependent) diabetes mellitus
SummaryDecreased release of nitric oxide from damaged endothelium is responsible for the impaired endothelium-dependent vasodilator responses found in animal models of vascular disease. DietaryExpand
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Oxidative stress and erythrocyte membrane fluidity in patients undergoing regular dialysis.
Oxidative damage due to free radical production is increased in uraemic patients and has been suggested as a possible factor contributing to the anaemia of chronic renal failure (CRF) and theExpand
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Increased superoxide production in hypertensive patients with diabetes mellitus: role of nitric oxide synthase.
BACKGROUND Hypertension and diabetes are important independent risk factors for increased oxidative stress and increased cardiovascular risk. The combination of hypertension and diabetes results in aExpand
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Severity of overdose after restriction of paracetamol availability: retrospective study
Paracetamol overdose is the commonest cause of intentional self harm in the United Kingdom, accounting for approximately 70 000 cases per year.1 It is the commonest cause of acute liver failure,1Expand
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Digoxin Withdrawal After Cardiac Failure in Patients with Sinus Rhythm
A double-blind placebo-controlled crossover trial of digoxin withdrawal was undertaken in 22 patients with sinus rhythm who had a previous history of frank heart failure and were taking therapeuticExpand
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The effects of oral methionine and homocysteine on endothelial function
BACKGROUND Raised homocysteine is a risk factor for vascular disease. Homocysteine is formed from methionine, and dietary manipulation of homocysteine in primates and humans with oral methionine isExpand
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