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Toward better drug repositioning: prioritizing and integrating existing methods into efficient pipelines.
Recycling old drugs, rescuing shelved drugs and extending patents' lives make drug repositioning an attractive form of drug discovery. Drug repositioning accounts for approximately 30% of the newly… Expand
Safety and tolerability of the first-in-class agent CPI-613 in combination with modified FOLFIRINOX in patients with metastatic pancreatic cancer: a single-centre, open-label, dose-escalation, phase…
BACKGROUND Pancreatic cancer statistics are dismal, with a 5-year survival of less than 10%, and more than 50% of patients presenting with metastatic disease. Metabolic reprogramming is an emerging… Expand
Modeling the relationship of epigenetic modifications to transcription factor binding
Transcription factors (TFs) and epigenetic modifications play crucial roles in the regulation of gene expression, and correlations between the two types of factors have been discovered. However,… Expand
Loss of XIST in Breast Cancer Activates MSN-c-Met and Reprograms Microglia via Exosomal miRNA to Promote Brain Metastasis.
Up to 30% of patients with metastatic breast cancer eventually develop brain metastasis, yet the pathologic mechanism behind this development remains poorly understood. Here, we profiled long… Expand
Tumour-specific amplitude-modulated radiofrequency electromagnetic fields induce differentiation of hepatocellular carcinoma via targeting Cav3.2 T-type voltage-gated calcium channels and Ca2+ influx
Background Administration of amplitude modulated 27·12 MHz radiofrequency electromagnetic fields (AM RF EMF) by means of a spoon-shaped applicator placed on the patient's tongue is a newly approved… Expand
Tumor mutational burden is a determinant of immune-mediated survival in breast cancer
ABSTRACT Mounting evidence supports a role for the immune system in breast cancer outcomes. The ability to distinguish highly immunogenic tumors susceptible to anti-tumor immunity from weakly… Expand
Hubs with Network Motifs Organize Modularity Dynamically in the Protein-Protein Interaction Network of Yeast
Background It has been recognized that modular organization pervades biological complexity. Based on network analysis, ‘party hubs’ and ‘date hubs’ were proposed to understand the basic principle of… Expand
Discovering functions and revealing mechanisms at molecular level from biological networks
With the increasingly accumulated data from high‐throughput technologies, study on biomolecular networks has become one of key focuses in systems biology and bioinformatics. In particular, various… Expand
A novel method of transcriptional response analysis to facilitate drug repositioning for cancer therapy.
Little research has been done to address the huge opportunities that may exist to reposition existing approved or generic drugs for alternate uses in cancer therapy. In addition, there has been… Expand
The knowledge-integrated network biomarkers discovery for major adverse cardiac events.
The mass spectrometry (MS) technology in clinical proteomics is very promising for discovery of new biomarkers for diseases management. To overcome the obstacles of data noises in MS analysis, we… Expand