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Simultaneous measurements of cardiac noradrenaline spillover and sympathetic outflow to skeletal muscle in humans.
1. Muscle sympathetic nerve activity (MSA) was recorded in the peroneal nerve at the knee by microneurography in ten healthy subjects and determinations were made simultaneously of intra‐arterial… Expand
Increased suicide rate in the middle-aged and its association with hours of sunlight.
- G. Lambert, C. Reid, D. Kaye, G. Jennings, M. Esler
- The American journal of psychiatry
- 1 April 2003
OBJECTIVE Aside from diminished daily functional capacity, individuals with depression are at greatly higher risk of suicide. Given that both endogenous depression severity and the incidence of… Expand
The neuronal noradrenaline transporter, anxiety and cardiovascular disease
- M. Esler, Marlies E. Alvarenga, +10 authors G. Lambert
- Psychology, Medicine
- Journal of psychopharmacology
- 1 July 2006
Panic disorder can serve as a clinical model for testing whether mental stress can cause heart disease. Potential neural mechanisms of cardiac risk are the sympathetic activation during panic… Expand
Measurement of overall and cardiac norepinephrine release into plasma during cognitive challenge
Measurements of plasma norepinephrine concentrations and norepinephrine spillover into plasma were used to gauge sympathetic nervous system activation during cognitive challenge (forced mental… Expand
Proliferation of Neointimal Smooth Muscle Cells after Arterial Injury
- A. Agrotis, P. Kanellakis, +5 authors A. Bobik
- Biology, Medicine
- Journal of Biological Chemistry
- 1 October 2004
The growth factor signaling mechanisms responsible for neointimal smooth muscle cell (SMC) proliferation and accumulation, a characteristic feature of many vascular pathologies that can lead to… Expand
Norepinephrine spillover at rest and during submaximal exercise in young and old subjects.
Aging is associated with elevations in plasma norepinephrine concentrations. The purpose of this investigation was to examine total body and regional norepinephrine spillover as an indicator of… Expand
Myocardial endothelin-1 release and indices of inflammation during angioplasty for acute myocardial infarction and stable coronary artery disease.
BACKGROUND Elevations in endothelin-1 (ET-1) and inflammatory cytokines may impair myocardial reperfusion through the induction of microvascular constriction or obstruction; however, the generation… Expand
The influence of aging on the human sympathetic nervous system and brain norepinephrine turnover.
- M. Esler, J. Hastings, G. Lambert, D. Kaye, G. Jennings, D. Seals
- Psychology, Medicine
- American journal of physiology. Regulatory…
- 1 March 2002
Investigating aging effects on the sympathetic nervous system and ascertaining underlying central nervous system (CNS) mechanisms mediating sympathetic stimulation is clinically pertinent because of… Expand
Increased brain serotonin turnover in panic disorder patients in the absence of a panic attack: Reduction by a selective serotonin reuptake inhibitor
Since the brain neurotransmitter changes characterising panic disorder remain uncertain, we quantified brain noradrenaline and serotonin turnover in patients with panic disorder, in the absence of a… Expand
Tranilast Prevents Activation of Transforming Growth Factor-&bgr; System, Leukocyte Accumulation, and Neointimal Growth in Porcine Coronary Arteries After Stenting
- M. Ward, A. Agrotis, P. Kanellakis, J. Hall, G. Jennings, A. Bobik
- Arteriosclerosis, thrombosis, and vascular…
- 1 June 2002
N (3,4-Dimethoxycinnamoyl) anthranilic acid (tranilast) prevents the synchronous upregulation of isoforms and receptors of the transforming growth factor (TGF)-&bgr; system after arterial injury and… Expand