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Effect of hypothyroidism on hormone profiles in virgin, pregnant and lactating rats, and on lactation.
Thyroid dysfunctions can produce reproductive problems. Untreated maternal hypothyroidism has serious consequences on development of offspring, resulting in stunted growth and mental retardation. The… Expand
Effects of hypothyroidism on mammary and liver lipid metabolism in virgin and late-pregnant rats Published, JLR Papers in Press, March 1, 2005. DOI 10.1194/jlr.M400325-JLR200
Untreated maternal hypothyroidism (hypoT) has serious consequences in offspring development that may result from the effect on lactation of maternal metabolism dysfunction. We studied the effects of… Expand
Prolactin receptor gene expression in rat mammary gland and liver during pregnancy and lactation.
The expression of two forms of PRL receptor messenger RNA was measured at different stages of pregnancy and lactation in mammary gland and liver from Sprague-Dawley rats, using 32P-labeled… Expand
Correlation of growth hormone secretion during pregnancy with circulating prolactin in rats.
Growth hormone (GH) concentrations were measured throughout pregnancy in rats. The effects of surgical stress, ovariectomy, and treatments with the antiprogesterone mifepristone (RU 486) or the… Expand
In vivo study of prolactin (PRL) intracellular signalling during lactogenesis in the rat: JAK/STAT pathway is activated by PRL in the mammary gland but not in the liver.
The rat prolactin receptor (PRL-R) exists in two forms, which differ in the length of the cytoplasmic domains, tissue distribution, and biological activity. The short form predominates in liver while… Expand
Reduction of mammary and liver lipogenesis and alteration of milk composition during lactation in rats by hypothyroidism.
- M. B. Hapon, S. M. Varas, M. Giménez, G. Jahn
- Biology, Medicine
- Thyroid : official journal of the American…
- 5 February 2007
OBJECTIVE The profound impairment in litter growth produced by untreated maternal hypothyroidism (HypoT) may be a consequence of maternal metabolic dysfunctions affecting lactation. In this work we… Expand
Effect of chronic thyroxine treatment on IGF-I, IGF-II and IGF-binding protein expression in mammary gland and liver during pregnancy and early lactation in rats.
- R. Rosato, D. Lindenbergh-Kortleve, J. Neck, S. Drop, G. Jahn
- Biology, Medicine
- European journal of endocrinology
- 1 May 2002
OBJECTIVE Hyperthyroidism in rats produces organ hypertrophy and increases in circulating IGF-I and IGF-binding protein (IGFBP)-3. Chronic treatment with thyroxine (T(4)) during pregnancy advances… Expand
Feedback regulation by progesterone of stress-induced prolactin release in rats.
We have previously found that modifications to serum progesterone concentration have profound inhibitory effects on prolactin release in response to ether stress. The objective of the present study… Expand
RPR 119990, a novel alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid antagonist: synthesis, pharmacological properties, and activity in an animal model of amyotrophic lateral sclerosis.
- T. Canton, G. Böhme, +16 authors J. Pratt
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 October 2001
Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor antagonists are of potential interest for the treatment of certain acute and chronic neurodegenerative diseases,… Expand
Effects of chronic thyroid hormone administration on pregnancy, lactogenesis and lactation in the rat.
We studied the effects of daily administration of 1 mg/kg thyroxine (T4) starting 10-15 days before mating, on parturition, maternal behavior and lactation in rats. Treated rats had elevated serum… Expand