• Publications
  • Influence
Heavy metal poisoning: the effects of cadmium on the kidney
The heavy metal cadmium (Cd) is known to be a widespread environmental contaminant and a potential toxin that may adversely affect human health. Exposure is largely via the respiratory orExpand
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Cadmium-induced autophagy in rat kidney: an early biomarker of subtoxic exposure.
Environmental exposures to cadmium (Cd) are a major cause of human toxicity. The kidney is the most sensitive organ; however, the natures of injuries and of adaptive responses have not beenExpand
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Effect of Heavy Metals on, and Handling by, the Kidney
Heavy metals such as cadmium (Cd), mercury (Hg), lead (Pb), chromium (Cr) and platinum (Pt) are a major environmental and occupational hazard. Unfortunately, these non-essential elements are toxic atExpand
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Physiological regulation of phosphate by vitamin D, parathyroid hormone (PTH) and phosphate (Pi)
  • G. Jacquillet, R. Unwin
  • Chemistry, Medicine
  • Pflügers Archiv - European Journal of Physiology
  • 5 November 2018
Inorganic phosphate (Pi) is an abundant element in the body and is essential for a wide variety of key biological processes. It plays an essential role in cellular energy metabolism and cellExpand
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Zinc and Cadmium Interactions in a Renal Cell Line Derived from Rabbit Proximal Tubule
Background: The aim of this work was to characterize the relationship between zinc (Zn<sup>2+</sup>) and cadmium (Cd<sup>2+</sup>) and the toxic effects of Cd<sup>2+</sup> in immortalized renalExpand
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Urinary vesicles: in splendid isolation.
Urine provides an attractive, non-invasive alternative to tissue, blood or other biofluid as a potential source of biomarkers of systemic and renal disease. The urinary protein content can be dividedExpand
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Protease stimulation of renal sodium reabsorption in vivo by activation of the collecting duct epithelial sodium channel (ENaC).
BACKGROUND Proteases can increase the activity of the epithelial sodium channel (ENaC) by cleaving its α- or γ-subunit. However, evidence so far comes only from studies in vitro in eitherExpand
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Potential Role of Serine Proteases in Modulating Renal Sodium Transport in vivo
The maintenance of sodium (Na+) homeostasis is an essential function of the kidney. It is achieved by a variety of transport processes localized all along the highly specialised segments of theExpand
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The renal and blood pressure response to low sodium diet in P2X4 receptor knockout mice
In the kidney, purinergic (P2) receptor‐mediated ATP signaling has been shown to be an important local regulator of epithelial sodium transport. Appropriate sodium regulation is crucial for bloodExpand
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Acute saccharin infusion has no effect on renal glucose handling in normal rats in vivo
Artificial sweeteners are extensively used by the food industry to replace sugar in food and beverages and are widely considered to be a healthy alternative. However, recent data suggest thatExpand
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