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- Publications
- Influence
A functional classification scheme for beta-lactamases and its correlation with molecular structure.
- K. Bush, G. Jacoby, A. A. Medeiros
- Chemistry, Medicine
- Antimicrobial agents and chemotherapy
- 1 June 1995
A classification scheme for b-lactamases based on functional characteristics is presented. Three major groups of enzymes are defined by their substrate and inhibitor profiles: group 1… Expand
AmpC β-Lactamases
- G. Jacoby
- Biology, Medicine
- Clinical Microbiology Reviews
- 1 January 2009
SUMMARY AmpC β-lactamases are clinically important cephalosporinases encoded on the chromosomes of many of the Enterobacteriaceae and a few other organisms, where they mediate resistance to… Expand
Updated Functional Classification of β-Lactamases
ABSTRACT Two classification schemes for β-lactamases are currently in use. The molecular classification is based on the amino acid sequence and divides β-lactamases into class A, C, and D enzymes… Expand
The worldwide emergence of plasmid-mediated quinolone resistance.
- A. Robicsek, G. Jacoby, D. Hooper
- Biology, Medicine
- The Lancet. Infectious diseases
- 1 October 2006
Fluoroquinolone resistance is emerging in gram-negative pathogens worldwide. The traditional understanding that quinolone resistance is acquired only through mutation and transmitted only vertically… Expand
Plasmid-Mediated Quinolone Resistance: a Multifaceted Threat
- J. Strahilevitz, G. Jacoby, D. Hooper, A. Robicsek
- Biology, Medicine
- Clinical Microbiology Reviews
- 1 October 2009
SUMMARY Although plasmid-mediated quinolone resistance (PMQR) was thought not to exist before its discovery in 1998, the past decade has seen an explosion of research characterizing this phenomenon.… Expand
Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase
- A. Robicsek, J. Strahilevitz, +5 authors D. C. Hooper
- Biology, Medicine
- Nature Medicine
- 2006
Antimicrobial-modifying resistance enzymes have traditionally been class specific, having coevolved with the antibiotics they inactivate. Fluoroquinolones, antimicrobial agents used extensively in… Expand
qnr Prevalence in Ceftazidime-Resistant Enterobacteriaceae Isolates from the United States
- A. Robicsek, J. Strahilevitz, D. Sahm, G. Jacoby, D. Hooper
- Biology, Medicine
- Antimicrobial Agents and Chemotherapy
- 1 August 2006
ABSTRACT We screened 313 ceftazidime-resistant Enterobacteriaceae isolates obtained in the United States from 1999 to 2004 for all three known qnr genes. A qnr gene was present in 20% of Klebsiella… Expand
Quinolone resistance from a transferable plasmid
- L. Martinez-Martinez, Á. Pascual, G. Jacoby
- Biology, Medicine
- The Lancet
- 14 March 1998
BACKGROUND
Bacteria can mutate to acquire quinolone resistance by target alterations or diminished drug accumulation. Plasmid-mediated resistance to quinolones in clinical isolates has been claimed… Expand
Mechanisms of resistance to quinolones.
- G. Jacoby
- Biology, Medicine
- Clinical infectious diseases : an official…
- 15 July 2005
The increased use of fluoroquinolones has led to increasing resistance to these antimicrobials, with rates of resistance that vary by both organism and geographic region. Resistance to… Expand
Plasmid-Mediated Quinolone Resistance in Clinical Isolates of Escherichia coli from Shanghai, China
- M. Wang, J. H. Tran, G. Jacoby, Ying-yuan Zhang, Fu Wang, D. Hooper
- Biology, Medicine
- Antimicrobial Agents and Chemotherapy
- 1 July 2003
ABSTRACT Although quinolone resistance usually results from chromosomal mutations, recent studies indicate that quinolone resistance can also be plasmid mediated. The gene responsible, qnr, is… Expand