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Recognition of a Gene Involved in the Regulation of Nicotinamide Adenine Dinucleotide Biosynthesis
Mutations affecting the biosynthesis of quinolinic acid, a precursor of nicotinamide adenine dinucleotide (NAD) in Escherichia coli K-12, are either near min 17 (nadA mutants) or near min 49 on the
Characterization of the nadR locus in Escherichia coli.
  • G. J. Tritz
  • Biology
    Canadian journal of microbiology
  • 1 February 1974
The biosynthesis of nicotinamide adenine dinucleotide (NAD) is under the genetic control of the nadR+ locus. The nadR+ allele is dominant to the nadR allele in transheterogenotes, indicating that t...
Azaserine resistance in Escherichia coli: chromosomal location of multiple genes
Transport studies demonstrate that mutants harboring lesions in the azaA gene are not defective in the transport of the aromatic amino acids, but that mutants which harbor lesions inThe azaB gene are defective in phenylalanine transport but not in tyrosine or tryptophan transport.
Chromosomal Location of the C Gene Involved in the Biosynthesis of Nicotinamide Adenine Dinucleotide in Escherichia coli K-12
A gene involved in the synthesis of nicotinamide adenine dinucleotide has been found to be cotransducible with the genes involved in the utilization of arabinose (ara) and the biosynthesis of leucine
Mapping of the nadB Locus Adjacent to a Previously Undescribed Purine Locus in Escherichia coli K-12
It is proposed that all mutants blocked in the de novo pathway of nicotinamide adenine dinucleotide biosynthesis be designated nad rather than nic and mutants blocking in the pyridine nucleotide cycle be designated pnc.
Mode of Nicotinamide Adenine Dinucleotide Utilization by Escherichia coli
Exogenous nicotinamide adenine dinucleotide is not utilized per se by Escherichia coli, but is converted to nicotinamide and thence to nicotinamide adenine dinucleotide via nicotinate.
Cross-Feeding of Escherichia coli Mutants Defective in the Biosynthesis of Nicotinamide Adenine Dinucleotide
Mutants of Escherichia coli defective in the biosynthesis of nicotinamide adenine dinucleotide are able to grow in a Casamino Acids medium lacking NAD and its immediate precursors, nicotinic acid and Nicotinamide, providing a means of isolating the intermediate, prequinolinic acid, as well as a biological assay for the compound.
Isolation of a metabolite capable of differentially supporting the growth of nicotinamide adenine dinucleotide auxotrophs of Escherichia coli
A compound, isolated from the culture fluid of a nadC auxotroph of Escherichia coli grown in a minimal medium, supports the growth of both a nnA and a ndB mutant, which may be the precursor of quinolinic acid, an intermediate in the biosynthesis of nicotinamide adenosine dinucleotide.
Detection of precursors of quinolinic acid in Escherichia coli.
A technique is described which allows the detection of precursors of quinolinic acid produced by Escherichia coli, independent of a bioassay. This is based on a double autoradiogram utilizing