Author pages are created from data sourced from our academic publisher partnerships and public sources.
Discriminative effects of morphine in the squirrel monkey.
- G. J. Schaefer, S. G. Holzman
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 April 1977
Squirrel monkeys were trained in a two-choice discrete trial avoidance task to discriminate between intramuscular injections of saline and 3.0 mg/kg of morphine. Morphine (0.1-10 mg/kg) produced a… Expand
Changes in response rates and reinforcement thresholds for intracranial self-stimulation during morphine withdrawal
Rats were implanted with stimulating electrodes in the medial forebrain bundle-lateral hypothalamus and were trained in an auto-titration brain self-stimulation paradigm. When response rates and… Expand
Task-specific effects of nicotine in rats: Intracranial self-stimulation and locomotor activity
The acute effects of nicotine (0.03-1.0 mg/kg) were studied in a locomotor activity procedure and in a series of intracranial self-stimulation (ICSS) paradigms. Nicotine produced a dose-dependent… Expand
Morphine withdrawal produces differential effects on the rate of lever-pressing for brain self-stimulation in the hypothalamus and midbrain in rats
Rats were implanted with stimulating electrodes either in the medial forebrain bundle-lateral hypothalamus (MFB-LH) or the midbrain-central gray area (MID-CG), and were trained to lever-press for… Expand
Opiate antagonists and rewarding brain stimulation
- G. J. Schaefer
- Psychology, Medicine
- Neuroscience & Biobehavioral Reviews
- 1 March 1988
This review examines the literature on the effects of opiate antagonists on brain stimulation (ICSS) reward. Antagonists should have predictable effects if endogenous opioids modulate ICSS. Naloxone… Expand
Discriminative properties of narcotic antagonists.
There have been many recent reports characterizing the discriminative properties of morphine and related narcotic analgesics in a variety of experimental paradigms, predominantly in the rat (see… Expand
Free-operant and auto-titration brain self-stimulation procedures in the rat: A comparison of drug effects
- G. J. Schaefer, S. G. Holtzman
- Psychology, Medicine
- Pharmacology Biochemistry and Behavior
- 31 January 1979
Rats were implanted with bipolar stimulating electrodes aimed at the medial forebrain bundle of the lateral hypothalamus, and trained to press a lever in one of two different procedures in order to… Expand
Interactions between alcohol and nicotine on intracranial self-stimulation and locomotor activity in rats.
These studies were aimed at investigating interactions between alcohol and nicotine on operant behavior and on locomotor activity. Independent groups of rats with electrodes in the lateral… Expand
Schedule-controlled brain self-stimulation: Has it utility for behavioral pharmacology?
We review evidence that schedule-controlled intracranial self-stimulation (ICSS) has properties in common with conventional reinforcements, such as food and water, but unlike the latter, animals will… Expand
Self-training for brain stimulation in the medial forebrain bundle of rats: A comparison of saline with amphetamine
Rats were implanted with stimulating electrodes in the medial forebrain bundle-lateral hypothalamus (MFB-LH). Following recovery from surgery, they were placed in 3 groups prior to brain… Expand