• Publications
  • Influence
Global view of the evolution and diversity of metazoan neuropeptide signaling
  • G. Jékely
  • Biology
    Proceedings of the National Academy of Sciences
  • 1 May 2013
TLDR
A global view of metazoan pNP diversity and evolution is obtained using similarity-based clustering and sensitive similarity searches and reveals a large and diffuse network of sequences connected by significant sequence similarity encompassing one-quarter of all families.
The neuropeptide complement of the marine annelid Platynereis dumerilii
TLDR
The large repertoire of conserved pNPs in Platynereis highlights the usefulness of annelids in comparative neuroendocrinology and establishes a reference dataset for comparative peptidomics in lophotrochozoans.
Hrs mediates downregulation of multiple signalling receptors in Drosophila
TLDR
It is found that Drosophila epithelial cells devoid of Hrs accumulate multiple signalling receptors in an endosomal compartment with high levels of ubiquitinated proteins: not only RTKs (EGFR and PVR) but also Notch and receptors for Hedgehog and Dpp (TGF‐β related).
Evolution of intraflagellar transport from coated vesicles and autogenous origin of the eukaryotic cilium.
TLDR
It is suggested that the initial step in the autogenous origin of the cilium was the establishment of a membrane patch with transmembrane proteins transported by the ancestral vesicle-coating IFT complex, which shares common ancestry with all protocoatomer derivatives, including all vesicles coats and the nuclear pore complex.
Evolution of phototaxis
  • G. Jékely
  • Biology
    Philosophical Transactions of the Royal Society B…
  • 12 October 2009
TLDR
It is relatively easy to evolve phototaxis once cell polarity, ciliary swimming and a stable cell shape are present, and a series of elementary evolutionary steps, each of potential selective advantage, which can lead to pelagic phototactic navigation are defined.
Small GTPases and the evolution of the eukaryotic cell.
  • G. Jékely
  • Biology
    BioEssays : news and reviews in molecular…
  • 1 November 2003
TLDR
The phylogeny of small GTPases suggests that the first endomembranes to evolve during eukaryote evolution had secretory, and not phagocytic, function.
The evolution of nervous system centralization
TLDR
Comparing neurodevelopment in slow-evolving deuterostome and protostome invertebrates reveals aspects of neurodevelopment that most likely occurred already in a similar manner in the last common ancestor of the bilaterians, Urbilateria.
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