• Publications
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Autocrine and paracrine regulation of melanocytes in human skin and in pigmentary disorders.
  • G. Imokawa
  • Biology, Medicine
  • Pigment cell research
  • 1 April 2004
Recently melanogenic paracrine or autocrine cytokine networks have been discovered in vitro between melanocytes and other types of skin cells. These include endothelin (ET)-1, granulocyte macrophageExpand
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Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin?
Stratum corneum lipids are an important determinant for both water-retention function and permeability-barrier function in the stratum corneum. However, their major constituent, ceramides, have notExpand
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Endothelins secreted from human keratinocytes are intrinsic mitogens for human melanocytes.
We recently demonstrated that human melanocyte proliferation and differentiation could be stimulated by endothelin (ET) derivatives via a receptor-mediated signal transduction pathway (Yada, Y.,Expand
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Age‐related changes in the elastic properties and thickness of human facial skin
Using recently designed, commercially available, non‐invasive instruments, we measured the thickness and elasticity of the skin of the face and ventral forearm in 170 women, and evaluated the effectsExpand
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Tyrosinase related protein 1 (TRP1) functions as a DHICA oxidase in melanin biosynthesis.
Several genes critical to the enzymatic regulation of melanin production in mammals have recently been cloned and mapped to the albino, brown and slaty loci in mice. All three genes encode proteinsExpand
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Modulation of melanogenic protein expression during the switch from eu- to pheomelanogenesis.
Mammalian melanocytes can produce two basic types of melanin, eumelanin and pheomelanin, within discrete organelles termed melanosomes. The physiological signals that regulate this switch areExpand
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Signalling mechanisms of endothelin-induced mitogenesis and melanogenesis in human melanocytes.
To understand the signalling mechanisms involved in the dual stimulatory effects of endothelin-1 (ET-1) on DNA synthesis and melanization in cultured human melanocytes, we analysed the biologicalExpand
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Characterization of the lipid composition at the proximal root regions of human hair.
The hair lipid composition collected from 44 Japanese females between 1 and 81 years of age was examined for eight lipids including hydrocarbons (HCs), squalene (SQ), wax esters (WEs), triglyceridesExpand
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The Pmel 17/silver locus protein. Characterization and investigation of its melanogenic function.
The silver mutation in mice causes progressive graying of hair due to the loss of functional follicular melanocytes. Recently the silver locus gene (called Pmel 17) has been cloned; its encodedExpand
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Epistatic connections between microphthalmia‐associated transcription factor and endothelin signaling in Waardenburg syndrome and other pigmentary disorders
Waardenburg syndrome (WS) is an inherited sensorineural deafness condition in humans caused by melanocyte deficiencies in the inner ear and forelock. Mutation of microphthalmia‐associatedExpand
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