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Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin?
- G. Imokawa, A. Abe, K. Jin, Y. Higaki, M. Kawashima, A. Hidano
- MedicineThe Journal of investigative dermatology
- 1 April 1991
Findings suggest that an insufficiency of ceramides in the stratum corneum is an etiologic factor in atopic dry skin.
Autocrine and paracrine regulation of melanocytes in human skin and in pigmentary disorders.
- G. Imokawa
- Medicine, BiologyPigment cell research
- 1 April 2004
The unveiled regulatory mechanisms involved in the abnormal up- or down-regulated levels of lesional melanocyte function provide new insights into therapeutic tools utilizing blockage of responsible cytokine networks.
Endothelins secreted from human keratinocytes are intrinsic mitogens for human melanocytes.
Age‐related changes in the elastic properties and thickness of human facial skin
- Y. Takema, Y. Yorimoto, M. Kawai, G. Imokawa
- MedicineThe British journal of dermatology
- 1 November 1994
Skin thickness decreased with age in ventral forearm skin, but increased significantly in the skin of the forehead, corners of the eyes, and cheeks, which are markedly exposed to sunlight.
Modulation of melanogenic protein expression during the switch from eu- to pheomelanogenesis.
- T. Kobayashi, W. Vieira, B. Potterf, C. Sakai, G. Imokawa, V. Hearing
- BiologyJournal of cell science
- 1 June 1995
There was no detectable expression of TRP1 or TRP2, or either of their enzymatic activities, inhair bulbs of lethal yellow (Ay/a) newborn mice, and tyrosinase activity was present at a reduced level compared to that found in hair bulbs of black (a/a" newborn mice.
Signalling mechanisms of endothelin-induced mitogenesis and melanogenesis in human melanocytes.
Results suggest that ET-induced dual cellular events in human melanocytes are closely associated with cross-talk between the protein kinase C and A and tyrosine kinase pathways.
Characterization of the lipid composition at the proximal root regions of human hair.
The hair lipid composition was characterized by a predominant negative correlation between each lipid for groups A and B, which suggests that the endogenous lipids in group B serve as a barrier against the penetration of predominantly sebum-derived exogenous lipids (group A).
Tyrosinase related protein 1 (TRP1) functions as a DHICA oxidase in melanin biosynthesis.
The data demonstrate that the specific melanogenic function of TRP1 is the oxidation of 5,6‐dihydroxyindole‐2‐carboxylic acid (DHICA) to a carboxylated indole‐quinone at a down‐stream point in the melanin biosynthetic pathway.
Stratum corneum lipids serve as a bound-water modulator.
Findings strongly suggest that stratum corneum lipids serve a water-holding function through the formation of lamellar structures within the stratum Corneum.
The epidermal stem cell factor is over-expressed in lentigo senilis: implication for the mechanism of hyperpigmentation.
- H. Hattori, M. Kawashima, Y. Ichikawa, G. Imokawa
- Biology, MedicineThe Journal of investigative dermatology
- 1 May 2004
Findings suggest that in addition to the stimulated expression of the ET-1/ET(B)R cascade, the accentuated expression of SCF in lesional skin plays an important role in the mechanism involved in the epidermal hyperpigmentation of LS.